TY - JOUR
T1 - General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice
AU - Serbanescu, Mara A.
AU - Mathena, Reilley P.
AU - Xu, Jing
AU - Santiago-Rodriguez, Tasha
AU - Hartsell, Theresa L.
AU - Cano, Raul J.
AU - Mintz, Cyrus D.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia to investigate the effects of volatile anesthetics on the diversity and composition of the intestinal microbiome. After 4-hour exposure to isoflurane, we observed a decrease in bacterial diversity. Taxonomic alterations included depletion of several commensal bacteria including Clostridiales. These data identify volatile anesthetics as potential contributors to microbial dysbiosis in the postoperative patient.
AB - Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia to investigate the effects of volatile anesthetics on the diversity and composition of the intestinal microbiome. After 4-hour exposure to isoflurane, we observed a decrease in bacterial diversity. Taxonomic alterations included depletion of several commensal bacteria including Clostridiales. These data identify volatile anesthetics as potential contributors to microbial dysbiosis in the postoperative patient.
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U2 - 10.1213/ANE.0000000000003938
DO - 10.1213/ANE.0000000000003938
M3 - Article
C2 - 30489316
AN - SCOPUS:85064075805
SN - 0003-2999
VL - 129
SP - e126-e129
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 4
ER -