Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

S. Rafiq, D. Melzer, M. N. Weedon, H. Lango, R. Saxena, L. J. Scott, C. N A Palmer, A. D. Morris, M. I. McCarthy, L. Ferrucci, A. T. Hattersley, E. Zeggini, T. M. Frayling

Research output: Contribution to journalArticle

Abstract

Aims/hypothesis: There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk. Methods: We selected 46 variants: (1) eight variants known to alter circulating levels of inflammatory proteins, including those in the IL18, IL1RN, IL6R, MIF, PAI1 (also known as SERPINE1) and CRP genes; and (2) 38 variants known to predispose to autoimmune diseases, including type 1 diabetes. We tested the associations of these variants with type 2 diabetes using a meta-analysis of 4,107 cases and 5,187 controls from the Wellcome Trust Case Control Consortium, the Diabetes Genetics Initiative, and the Finland-United States Investigation of NIDDM studies. We followed up associated variants (p

Original languageEnglish (US)
Pages (from-to)2205-2213
Number of pages9
JournalDiabetologia
Volume51
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • Autoimmune disease
  • Genes
  • Genetic epidemiology
  • Inflammation
  • Mendelian randomisation
  • SNP
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Rafiq, S., Melzer, D., Weedon, M. N., Lango, H., Saxena, R., Scott, L. J., Palmer, C. N. A., Morris, A. D., McCarthy, M. I., Ferrucci, L., Hattersley, A. T., Zeggini, E., & Frayling, T. M. (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. https://doi.org/10.1007/s00125-008-1160-3