Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

S. Rafiq; D. Melzer; M. N. Weedon; H. Lango; R. Saxena; L. J. Scott; C. N A Palmer; A. D. Morris; M. I. McCarthy; L. Ferrucci; A. T. Hattersley; E. Zeggini; T. M. Frayling

doi:10.1007/s00125-008-1160-3

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

S. Rafiq, D. Melzer, M. N. Weedon, H. Lango, R. Saxena, L. J. Scott, C. N A Palmer, A. D. Morris, M. I. McCarthy, L. Ferrucci, A. T. Hattersley, E. Zeggini, T. M. Frayling

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37 Scopus citations

Abstract

Aims/hypothesis: There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk. Methods: We selected 46 variants: (1) eight variants known to alter circulating levels of inflammatory proteins, including those in the IL18, IL1RN, IL6R, MIF, PAI1 (also known as SERPINE1) and CRP genes; and (2) 38 variants known to predispose to autoimmune diseases, including type 1 diabetes. We tested the associations of these variants with type 2 diabetes using a meta-analysis of 4,107 cases and 5,187 controls from the Wellcome Trust Case Control Consortium, the Diabetes Genetics Initiative, and the Finland-United States Investigation of NIDDM studies. We followed up associated variants (p

Original language	English (US)
Pages (from-to)	2205-2213
Number of pages	9
Journal	Diabetologia
Volume	51
Issue number	12
DOIs	https://doi.org/10.1007/s00125-008-1160-3
State	Published - Dec 2008
Externally published	Yes

Keywords

Autoimmune disease
Genes
Genetic epidemiology
Inflammation
Mendelian randomisation
SNP
Type 2 diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/s00125-008-1160-3

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Rafiq, S., Melzer, D., Weedon, M. N., Lango, H., Saxena, R., Scott, L. J., Palmer, C. N. A., Morris, A. D., McCarthy, M. I., Ferrucci, L., Hattersley, A. T., Zeggini, E., & Frayling, T. M. (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. https://doi.org/10.1007/s00125-008-1160-3

Rafiq, S, Melzer, D, Weedon, MN, Lango, H, Saxena, R, Scott, LJ, Palmer, CNA, Morris, AD, McCarthy, MI, Ferrucci, L, Hattersley, AT, Zeggini, E & Frayling, TM 2008, 'Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes', Diabetologia, vol. 51, no. 12, pp. 2205-2213. https://doi.org/10.1007/s00125-008-1160-3

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abstract = "Aims/hypothesis: There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk. Methods: We selected 46 variants: (1) eight variants known to alter circulating levels of inflammatory proteins, including those in the IL18, IL1RN, IL6R, MIF, PAI1 (also known as SERPINE1) and CRP genes; and (2) 38 variants known to predispose to autoimmune diseases, including type 1 diabetes. We tested the associations of these variants with type 2 diabetes using a meta-analysis of 4,107 cases and 5,187 controls from the Wellcome Trust Case Control Consortium, the Diabetes Genetics Initiative, and the Finland-United States Investigation of NIDDM studies. We followed up associated variants (p",

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author = "S. Rafiq and D. Melzer and Weedon, {M. N.} and H. Lango and R. Saxena and Scott, {L. J.} and Palmer, {C. N A} and Morris, {A. D.} and McCarthy, {M. I.} and L. Ferrucci and Hattersley, {A. T.} and E. Zeggini and Frayling, {T. M.}",

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AU - Melzer, D.

AU - Weedon, M. N.

AU - Lango, H.

AU - Saxena, R.

AU - Scott, L. J.

AU - Palmer, C. N A

AU - Morris, A. D.

AU - McCarthy, M. I.

AU - Ferrucci, L.

AU - Hattersley, A. T.

AU - Zeggini, E.

AU - Frayling, T. M.

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Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

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