Gene transfer and cardiovascular disease

Elizabeth G. Nabel, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Through the introduction of foreign DNA into somatic cells, the aim of gene therapy is to correct or prevent disorders caused by the absence or malfunction of genes within a diseased individual. Expression of recombinant genes at specific sites within the vasculature can provide insights into vascular biology and potential treatments for various cardiovascular disorders. In our studies, we have developed methods for the transfer of recombinant genes into the endothelium and vascular smooth muscle cells by using retroviral vectors and liposomal transfection. Although these techniques are still in the formative stages, gene transfer into the endothelium and other vascular cells is a new approach to the treatment of vascular diseases, including atherosclerosis and restenosis.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume1
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

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Cardiovascular Diseases
Genes
Vascular Endothelium
Vascular Diseases
Vascular Smooth Muscle
Genetic Therapy
Smooth Muscle Myocytes
Endothelium
Transfection
Blood Vessels
Atherosclerosis
Gene Expression
DNA
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gene transfer and cardiovascular disease. / Nabel, Elizabeth G.; Nabel, Gary J.

In: Trends in Cardiovascular Medicine, Vol. 1, No. 1, 1991, p. 12-17.

Research output: Contribution to journalArticle

Nabel, Elizabeth G. ; Nabel, Gary J. / Gene transfer and cardiovascular disease. In: Trends in Cardiovascular Medicine. 1991 ; Vol. 1, No. 1. pp. 12-17.
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