Gene therapy for vascular disease

T. Finkel, S. E. Epstein

Research output: Contribution to journalArticlepeer-review

Abstract

Highly efficient methods that are now available allow for the genetic modification of cells that compose the vessel wall. The application of these gene transfer systems are already providing information that has enhanced our understanding of a variety of cellular processes relating to vascular biology. Recent experimental results using this technology also hold promise for more powerful therapeutic options in the treatment of vascular disease. This review discusses the most commonly used methods of gene transfer and details some current applications of these methodologies in animal models of vascular disease.

Original languageEnglish (US)
Pages (from-to)843-851
Number of pages9
JournalFASEB Journal
Volume9
Issue number10
StatePublished - 1995
Externally publishedYes

Keywords

  • adenoviruses
  • gene transfer
  • liposomes
  • retroviruses

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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