Gene structure and map location of the murine homolog of the Huntington- associated protein, Hap1

J. Nasir, K. Duan, K. Nichol, S. Engelender, R. Ashworth, V. Colomer, S. Thomas, C. M. Disteche, M. R. Hayden, C. A. Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Huntington's Disease (HD) is an inherited progressive neurodegenerative disorder associated with a mutation in a gene expressed in both affected and non-affected tissues. The selective neuropathology in HD is thought to be mediated in part through interactions with other proteins including the Huntington Associated Protein, HAP-1, which is predominantly expressed in the brain. We have mapped its murine homolog, Hap1, to mouse Chr 11 (band D), which shares extensive synteny with human Chr 17 including the region 17q21- q22, where the gene for 'frontotemporal dementia and parkinsonism linked to chromosome 17' has bee mapped. In addition, we have sequenced a 21,984 base pair (bp) genomic clone encompassing the entire Hap1 gene. It is organized as 11 exons and flanked by exons from potentially one or more novel genes. At least three Hap1 transcripts (Hap1-A; Hap1-B; Hap1-C) can be formed by alternative splicing at the 3' end of the gene leading to protein isoforms with novel C-termini.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalMammalian Genome
Volume9
Issue number7
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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