Gene regulation by non-coding RNAs

Veena S. Patil; Rui Zhou; Tariq M. Rana

doi:10.3109/10409238.2013.844092

Gene regulation by non-coding RNAs

Veena S. Patil, Rui Zhou, Tariq M. Rana

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.

Original language	English (US)
Pages (from-to)	16-32
Number of pages	17
Journal	Critical reviews in biochemistry and molecular biology
Volume	49
Issue number	1
DOIs	https://doi.org/10.3109/10409238.2013.844092
State	Published - Jan 2014
Externally published	Yes

Keywords

Gene silencing
LincRNAs
MiRNA
NcRNA
RNA complexes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3109/10409238.2013.844092

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abstract = "The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.",

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note = "Funding Information: This work was supported in part by grants from the National Institutes of Health to T.M.R. The authors declare no conflicts of interest.",

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AU - Zhou, Rui

AU - Rana, Tariq M.

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AB - The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.

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KW - MiRNA

KW - NcRNA

KW - RNA complexes

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Gene regulation by non-coding RNAs

Abstract

Keywords

ASJC Scopus subject areas

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