Gene regulation by non-coding RNAs

Veena S. Patil, Rui Zhou, Tariq M. Rana

Research output: Contribution to journalReview articlepeer-review

Abstract

The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.

Original languageEnglish (US)
Pages (from-to)16-32
Number of pages17
JournalCritical reviews in biochemistry and molecular biology
Volume49
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Gene silencing
  • LincRNAs
  • MiRNA
  • NcRNA
  • RNA complexes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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