Gene polymorphisms of IL-6-174 G/C and IL-1Ra VNTR in asthmatic children

Ahmad Settin, Magdy Zedan, Mohamed Farag, Mohammed Ezz El Regal, Engy Osman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To check for the association of genetic polymorphisms of IL-6--174G/C and IL-1RaVNTR with the susceptibility and severity of asthma in Egyptian children. Methods. Subjects included 69 asthmatic children and 98 healthy unrelated controls from the Nile Delta of Egypt. Cases consisted of 20 males and 49 females with an age mean± SD is 7.5 ± 2.1 ranging between 2-13 years. DNA amplification using PCR with sequence-specific primers was done for detection of promotor single nucleotide polymorphism of IL-6 gene as well as intron 2 VNTR of IL-1Ra gene. Frequency of case-genotypes or alleles were compared to controls using Fisher exact test and Odds ratio. Results. Cases showed significant higher frequency of the genotypes: IL-6-174 GG (P-174 GC and IL-1Ra A1A2 genotypes (P

Original languageEnglish (US)
Pages (from-to)1019-1023
Number of pages5
JournalIndian Journal of Pediatrics
Volume75
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Childhood asthma
  • Egypt
  • Interleukins
  • Polymorphism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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