TY - JOUR
T1 - Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma
T2 - NCI-SEER case-control study
AU - Lim, Unhee
AU - Wang, Sophia S.
AU - Hartge, Patricia
AU - Cozen, Wendy
AU - Kelemen, Linda E.
AU - Chanock, Stephen
AU - Davis, Scott
AU - Blair, Aaron
AU - Schenk, Maryjean
AU - Rothman, Nathaniel
AU - Lan, Qing
PY - 2007/4/1
Y1 - 2007/4/1
N2 - We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A>CCC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>CTT(OR = 0.67;95%CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in onecarbon metabolism supports their etiologic involvement in lymphomagenesis.
AB - We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A>CCC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>CTT(OR = 0.67;95%CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in onecarbon metabolism supports their etiologic involvement in lymphomagenesis.
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U2 - 10.1182/blood-2006-07-034330
DO - 10.1182/blood-2006-07-034330
M3 - Article
C2 - 17119116
AN - SCOPUS:33947593397
SN - 0006-4971
VL - 109
SP - 3050
EP - 3059
JO - Blood
JF - Blood
IS - 7
ER -