Gene-modified cells for the treatment of cancer

Katharine A. Whartenby, George N. Abraham, Peter A. Calabresi, Camille N. Abboud, Paul Calabresi, Aizen Marrogi, Scott M. Freeman

Research output: Contribution to journalReview article


Gene therapy involves the insertion of a gene into an organism to treat a disease. Since its early development in the 1970s, gene therapy has expanded rapidly both in terms of the methods available and the number of candidate diseases for treatment. This report reviews gene therapy for cancer, including methodology, pre-clinical studies and experimental clinical trials.

Original languageEnglish (US)
Pages (from-to)175-190
Number of pages16
JournalPharmacology and Therapeutics
Issue number1
StatePublished - 1995



  • Gene therapy
  • HSV-TK
  • bystander effect
  • cancer
  • cytokines
  • immunotherapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Whartenby, K. A., Abraham, G. N., Calabresi, P. A., Abboud, C. N., Calabresi, P., Marrogi, A., & Freeman, S. M. (1995). Gene-modified cells for the treatment of cancer. Pharmacology and Therapeutics, 66(1), 175-190.