Gene-modified cells for the treatment of cancer

Katharine Whartenby, George N. Abraham, Peter Calabresi, Camille N. Abboud, Paul Calabresi, Aizen Marrogi, Scott M. Freeman

Research output: Contribution to journalArticle

Abstract

Gene therapy involves the insertion of a gene into an organism to treat a disease. Since its early development in the 1970s, gene therapy has expanded rapidly both in terms of the methods available and the number of candidate diseases for treatment. This report reviews gene therapy for cancer, including methodology, pre-clinical studies and experimental clinical trials.

Original languageEnglish (US)
Pages (from-to)175-190
Number of pages16
JournalPharmacology and Therapeutics
Volume66
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

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Genetic Therapy
Genes
Neoplasms
Insertional Mutagenesis
Therapeutics
Clinical Trials
Clinical Studies

Keywords

  • bystander effect
  • cancer
  • cytokines
  • Gene therapy
  • HSV-TK
  • immunotherapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Whartenby, K., Abraham, G. N., Calabresi, P., Abboud, C. N., Calabresi, P., Marrogi, A., & Freeman, S. M. (1995). Gene-modified cells for the treatment of cancer. Pharmacology and Therapeutics, 66(1), 175-190. https://doi.org/10.1016/0163-7258(94)00081-D

Gene-modified cells for the treatment of cancer. / Whartenby, Katharine; Abraham, George N.; Calabresi, Peter; Abboud, Camille N.; Calabresi, Paul; Marrogi, Aizen; Freeman, Scott M.

In: Pharmacology and Therapeutics, Vol. 66, No. 1, 1995, p. 175-190.

Research output: Contribution to journalArticle

Whartenby, K, Abraham, GN, Calabresi, P, Abboud, CN, Calabresi, P, Marrogi, A & Freeman, SM 1995, 'Gene-modified cells for the treatment of cancer', Pharmacology and Therapeutics, vol. 66, no. 1, pp. 175-190. https://doi.org/10.1016/0163-7258(94)00081-D
Whartenby, Katharine ; Abraham, George N. ; Calabresi, Peter ; Abboud, Camille N. ; Calabresi, Paul ; Marrogi, Aizen ; Freeman, Scott M. / Gene-modified cells for the treatment of cancer. In: Pharmacology and Therapeutics. 1995 ; Vol. 66, No. 1. pp. 175-190.
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