Gene map of the extended human MHC

Roger Horton; Laurens Wilming; Vikki Rand; Ruth C. Lovering; Elspeth A. Bruford; Varsha K. Khodiyar; Michael J. Lush; Sue Povey; C. Conover Talbot; Mathew W. Wright; Hester M. Wain; John Trowsdale; Andreas Ziegler; Stephan Beck

doi:10.1038/nrg1489

Gene map of the extended human MHC

Roger Horton, Laurens Wilming, Vikki Rand, Ruth C. Lovering, Elspeth A. Bruford, Varsha K. Khodiyar, Michael J. Lush, Sue Povey, C. Conover Talbot, Mathew W. Wright, Hester M. Wain, John Trowsdale, Andreas Ziegler, Stephan Beck

Research output: Contribution to journal › Review article › peer-review

703 Scopus citations

Abstract

The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

Original language	English (US)
Pages (from-to)	889-899
Number of pages	11
Journal	Nature Reviews Genetics
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nrg1489
State	Published - Dec 2004
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1038/nrg1489

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title = "Gene map of the extended human MHC",

abstract = "The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.",

author = "Roger Horton and Laurens Wilming and Vikki Rand and Lovering, {Ruth C.} and Bruford, {Elspeth A.} and Khodiyar, {Varsha K.} and Lush, {Michael J.} and Sue Povey and Talbot, {C. Conover} and Wright, {Mathew W.} and Wain, {Hester M.} and John Trowsdale and Andreas Ziegler and Stephan Beck",

note = "Funding Information: We wish to thank S. Rogers and J. Kaufman for sharing prepublication data. The work of the HUGO Gene Nomenclature Committee is supported by the US National Institutes of Health, the UK Medical Research Council and the Wellcome Trust.",

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language = "English (US)",

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pages = "889--899",

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AU - Horton, Roger

AU - Wilming, Laurens

AU - Rand, Vikki

AU - Lovering, Ruth C.

AU - Bruford, Elspeth A.

AU - Khodiyar, Varsha K.

AU - Lush, Michael J.

AU - Povey, Sue

AU - Talbot, C. Conover

AU - Wright, Mathew W.

AU - Wain, Hester M.

AU - Trowsdale, John

AU - Ziegler, Andreas

AU - Beck, Stephan

N1 - Funding Information: We wish to thank S. Rogers and J. Kaufman for sharing prepublication data. The work of the HUGO Gene Nomenclature Committee is supported by the US National Institutes of Health, the UK Medical Research Council and the Wellcome Trust.

PY - 2004/12

Y1 - 2004/12

N2 - The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

AB - The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

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Gene map of the extended human MHC

Abstract

ASJC Scopus subject areas

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