Gene map of the extended human MHC

Roger Horton, Laurens Wilming, Vikki Rand, Ruth C. Lovering, Elspeth A. Bruford, Varsha K. Khodiyar, Michael J. Lush, Sue Povey, C. Conover Talbot, Mathew W. Wright, Hester M. Wain, John Trowsdale, Andreas Ziegler, Stephan Beck

Research output: Contribution to journalReview articlepeer-review

703 Scopus citations


The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

Original languageEnglish (US)
Pages (from-to)889-899
Number of pages11
JournalNature Reviews Genetics
Issue number12
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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