TY - JOUR
T1 - Gene expression profiling
T2 - From microarrays to medicine
AU - Weeraratna, Ashani T.
AU - Nagel, James E.
AU - De Mello-Coelho, Valeria
AU - Taub, Dennis D.
PY - 2004/5
Y1 - 2004/5
N2 - With the mapping of the human genome comes the ability to identify genes of interest in specific diseases and the pathways involved therein. Laboratory technology has evolved in parallel, providing us with the ability to assay thousands of these genes at once, a technique known as microarray analysis. The main question that this type of technology raises is how we can apply this powerful technology to clinical medicine. Recently, advances in data analysis, as well as standardization of the technology, have allowed us to examine this question, and indeed a few clinical trials currently being performed include microarrays as part of their protocol. In this review we outline the microarray technique and describe these types of studies in further detail.
AB - With the mapping of the human genome comes the ability to identify genes of interest in specific diseases and the pathways involved therein. Laboratory technology has evolved in parallel, providing us with the ability to assay thousands of these genes at once, a technique known as microarray analysis. The main question that this type of technology raises is how we can apply this powerful technology to clinical medicine. Recently, advances in data analysis, as well as standardization of the technology, have allowed us to examine this question, and indeed a few clinical trials currently being performed include microarrays as part of their protocol. In this review we outline the microarray technique and describe these types of studies in further detail.
KW - Clinic
KW - Gene expression
KW - Microarray
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=3543114422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3543114422&partnerID=8YFLogxK
U2 - 10.1023/B:JOCI.0000025443.44833.1d
DO - 10.1023/B:JOCI.0000025443.44833.1d
M3 - Review article
C2 - 15114052
AN - SCOPUS:3543114422
SN - 0271-9142
VL - 24
SP - 213
EP - 224
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 3
ER -