Gene expression profiles in HTLV-I-immortalized T cells: Deregulated expression of genes involved in apoptosis regulation

Edward W. Harhaj, Li Feng Good, Gutian Xiao, Shao Cong Sun

Research output: Contribution to journalArticle

Abstract

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell malignancy. A key step in HTLV-I-induced leukemigenesis is induction of abnormal T-cell growth and survival. Unlike antigen-stimulated T cells, which cease proliferation after a finite number of cell division, HTLV-I-infected T cells proliferate indefinitely (immortalized), thus facilitating occurrence of secondary genetic changes leading to malignant transformation. To explore the molecular basis of HTLV-I-induced abnormal T-cell survival, we compared the gene expression profiles of normal and HTLV-I-immortalized T cells using 'gene array', These studies revealed a strikingly altered expression pattern of a large number of genes along with HTLV-I-mediated T-cell immortalization. Interestingly, many of these deregulated genes are involved in the control of programmed cell death or apoptosis. These findings indicate that disruption of the cellular apoptosis-regulatory network may play a role in the HTLV-I-mediated oncogenesis.

Original languageEnglish (US)
Pages (from-to)1341-1349
Number of pages9
JournalOncogene
Volume18
Issue number6
DOIs
StatePublished - Feb 11 1999

Keywords

  • Adult T-cell leukemia
  • Gene array
  • Gene expression profile
  • HTLV-I
  • T-cell immortalization

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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