Gene expression in Plasmodium: From gametocytes to sporozoites

C. K. Moreira; M. T. Marrelli; M. Jacobs-Lorena

doi:10.1016/j.ijpara.2004.10.007

Gene expression in Plasmodium: From gametocytes to sporozoites

C. K. Moreira, M. T. Marrelli, M. Jacobs-Lorena

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Completion of the complex developmental program of Plasmodium in the mosquito is essential for parasite transmission, yet this part of its life cycle is still poorly understood. In recent years, considerable progress has been made in the identification and characterization of genes expressed during parasite development in the mosquito. This line of investigation was greatly facilitated by the availability of the genome sequence of several Plasmodium, and by the application of approaches such as proteomics, microarrays, gene disruption by homologous recombination (gene knockout) and by use of subtraction libraries. Here, we review what is presently known about genes expressed in gametocytes and during the Plasmodium life cycle in the mosquito.

Original language	English (US)
Pages (from-to)	1431-1440
Number of pages	10
Journal	International Journal for Parasitology
Volume	34
Issue number	13-14
DOIs	https://doi.org/10.1016/j.ijpara.2004.10.007
State	Published - Dec 2004

Keywords

Gene expression
Malaria
Plasmodium

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.ijpara.2004.10.007

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title = "Gene expression in Plasmodium: From gametocytes to sporozoites",

abstract = "Completion of the complex developmental program of Plasmodium in the mosquito is essential for parasite transmission, yet this part of its life cycle is still poorly understood. In recent years, considerable progress has been made in the identification and characterization of genes expressed during parasite development in the mosquito. This line of investigation was greatly facilitated by the availability of the genome sequence of several Plasmodium, and by the application of approaches such as proteomics, microarrays, gene disruption by homologous recombination (gene knockout) and by use of subtraction libraries. Here, we review what is presently known about genes expressed in gametocytes and during the Plasmodium life cycle in the mosquito.",

keywords = "Gene expression, Malaria, Plasmodium",

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AU - Marrelli, M. T.

AU - Jacobs-Lorena, M.

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AB - Completion of the complex developmental program of Plasmodium in the mosquito is essential for parasite transmission, yet this part of its life cycle is still poorly understood. In recent years, considerable progress has been made in the identification and characterization of genes expressed during parasite development in the mosquito. This line of investigation was greatly facilitated by the availability of the genome sequence of several Plasmodium, and by the application of approaches such as proteomics, microarrays, gene disruption by homologous recombination (gene knockout) and by use of subtraction libraries. Here, we review what is presently known about genes expressed in gametocytes and during the Plasmodium life cycle in the mosquito.

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Gene expression in Plasmodium: From gametocytes to sporozoites

Abstract

Keywords

ASJC Scopus subject areas

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