Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications

Research output: Contribution to journalReview article

Abstract

Purpose of Review: We identify the recent evidence for gene-by-environment interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as well as environmental exposures and how they interact to predict psychiatric disorders and psychiatric symptomatology. We direct our focus on the psychiatric outcomes that were focused on by the Psychiatric Genetics Consortium. Recent Findings: Many of the studies focus on candidate gene approaches, with most of the studies drawing upon previous literature to decide the genes of interest. Other studies used a genome-wide approach. While some studies demonstrated positive replication of previous findings, replication is still an issue within gene-by-environment interaction studies. Summary: Gene-by-environment interaction research in psychiatry globally suggests some susceptibility to environmental exposures based on genotype; however, greater clarity is needed around the idea that genetic risk may not be disorder specific.

Original languageEnglish (US)
Article number81
JournalCurrent psychiatry reports
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2019

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Gene-Environment Interaction
Psychiatry
Environmental Exposure
Genes
Genotype
Genome
Research

Keywords

  • Anxiety disorder
  • Bipolar disorder
  • Candidate genes
  • Genome-wide association
  • Major depressive disorder
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications",
abstract = "Purpose of Review: We identify the recent evidence for gene-by-environment interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as well as environmental exposures and how they interact to predict psychiatric disorders and psychiatric symptomatology. We direct our focus on the psychiatric outcomes that were focused on by the Psychiatric Genetics Consortium. Recent Findings: Many of the studies focus on candidate gene approaches, with most of the studies drawing upon previous literature to decide the genes of interest. Other studies used a genome-wide approach. While some studies demonstrated positive replication of previous findings, replication is still an issue within gene-by-environment interaction studies. Summary: Gene-by-environment interaction research in psychiatry globally suggests some susceptibility to environmental exposures based on genotype; however, greater clarity is needed around the idea that genetic risk may not be disorder specific.",
keywords = "Anxiety disorder, Bipolar disorder, Candidate genes, Genome-wide association, Major depressive disorder, Suicide",
author = "Musci, {Rashelle J.} and Augustinavicius, {Jura L.} and Heather Volk",
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AB - Purpose of Review: We identify the recent evidence for gene-by-environment interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as well as environmental exposures and how they interact to predict psychiatric disorders and psychiatric symptomatology. We direct our focus on the psychiatric outcomes that were focused on by the Psychiatric Genetics Consortium. Recent Findings: Many of the studies focus on candidate gene approaches, with most of the studies drawing upon previous literature to decide the genes of interest. Other studies used a genome-wide approach. While some studies demonstrated positive replication of previous findings, replication is still an issue within gene-by-environment interaction studies. Summary: Gene-by-environment interaction research in psychiatry globally suggests some susceptibility to environmental exposures based on genotype; however, greater clarity is needed around the idea that genetic risk may not be disorder specific.

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KW - Bipolar disorder

KW - Candidate genes

KW - Genome-wide association

KW - Major depressive disorder

KW - Suicide

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