TY - JOUR
T1 - Gene-environment interaction involving recently identified colorectal cancer susceptibility loci
AU - Kantor, Elizabeth D.
AU - Hutter, Carolyn M.
AU - Minnier, Jessica
AU - Berndt, Sonja I.
AU - Brenner, Hermann
AU - Caan, Bette J.
AU - Campbell, Peter T.
AU - Carlson, Christopher S.
AU - Casey, Graham
AU - Chan, Andrew T.
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J.
AU - Cotterchio, Michelle
AU - Du, Mengmeng
AU - Duggan, David
AU - Fuchs, Charles S.
AU - Giovannucci, Edward L.
AU - Gong, Jian
AU - Harrison, Tabitha A.
AU - Hayes, Richard B.
AU - Henderson, Brian E.
AU - Hoffmeister, Michael
AU - Hopper, John L.
AU - Jenkins, Mark A.
AU - Jiao, Shuo
AU - Kolonel, Laurence N.
AU - Marchand, Loic Le
AU - Lemire, Mathieu
AU - Ma, Jing
AU - Newcomb, Polly A.
AU - Ochs-Balcom, Heather M.
AU - Pflugeisen, Bethann M.
AU - Potter, John D.
AU - Rudolph, Anja
AU - Schoen, Robert E.
AU - Seminara, Daniela
AU - Slattery, Martha L.
AU - Stelling, Deanna L.
AU - Thomas, Fridtjof
AU - Thornquist, Mark
AU - Ulrich, Cornelia M.
AU - Warnick, Greg S.
AU - Zanke, Brent W.
AU - Peters, Ulrike
AU - Hsu, Li
AU - White, Emily
N1 - Publisher Copyright:
© 2014 AACR.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.Results: None of the permutation-adjusted P values reached statistical significance.Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.
AB - Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.Results: None of the permutation-adjusted P values reached statistical significance.Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.
UR - http://www.scopus.com/inward/record.url?scp=84907171250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907171250&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-14-0062
DO - 10.1158/1055-9965.EPI-14-0062
M3 - Article
C2 - 24994789
AN - SCOPUS:84907171250
SN - 1055-9965
VL - 23
SP - 1824
EP - 1833
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -