Gene delivery polymer structure-function relationships elucidated via principal component analysis

C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, S. Y. Tzeng, J. J. Green

Research output: Contribution to journalArticlepeer-review

Abstract

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

Original languageEnglish (US)
Pages (from-to)12134-12137
Number of pages4
JournalChemical Communications
Volume51
Issue number60
DOIs
StatePublished - Aug 4 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Gene delivery polymer structure-function relationships elucidated via principal component analysis'. Together they form a unique fingerprint.

Cite this