Gene carriers modified with PEG demonstrate increased transport and stability in mucus as explored with high-resolution nanoparticle tracking

Michelle Dawson, Denis Wirtz, Justin Hanes

Research output: Contribution to conferencePaper

Abstract

The modification of gene carriers with poly(ethylene glycols) (PEG) which demonstrated increased transport and stability in mucus as explored with high-resolution nanoparticle tracking was described. The average rate of transport of polyethylemine (PEI) or standard-sized polystyrene (PS) particles surface-modified with PEG increases by approximately 10-fold. The percentage of particles undergoing diffusive transport in mucus increases for PEI particles modified with PEG by approximately 10%. Particle formulations were optimized for rapid transport, stability in mucus, cell uptake, and trasfection efficiency in mucus-covered lung or gastrointentinal (GI) cells.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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