Abstract
Inter-individual variability in blood pressure (BP) is influenced by both genetic and nongenetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/ psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.
Original language | English (US) |
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Article number | 1596 |
Journal | International journal of environmental research and public health |
Volume | 14 |
Issue number | 12 |
DOIs | |
State | Published - Dec 18 2017 |
Keywords
- Blood pressure
- Chronic burden
- Depression
- Gene-by-environment interaction
- Genetics
- Hypertension
- Non-burden test
- Psychosocial factors
- Socioeconomic status
ASJC Scopus subject areas
- Pollution
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis