Gene-by-psychosocial factor interactions influence diastolic blood pressure in european and african ancestry populations: Meta-analysis of four cohort studies

Jennifer A. Smith, Wei Zhao, Kalyn Yasutake, Carmella August, Scott M. Ratliff, Jessica D. Faul, Eric Boerwinkle, Aravinda Chakravarti, Ana V.Diez Roux, Yan Gao, Michael E. Griswold, Gerardo Heiss, Sharon L.R. Kardia, Alanna C. Morrison, Solomon K. Musani, Stanford Mwasongwe, Kari E. North, Kathryn M. Rose, Mario Sims, Yan V. SunDavid R. Weir, Belinda L. Needham

Research output: Contribution to journalArticlepeer-review

Abstract

Inter-individual variability in blood pressure (BP) is influenced by both genetic and nongenetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/ psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.

Original languageEnglish (US)
Article number1596
JournalInternational journal of environmental research and public health
Volume14
Issue number12
DOIs
StatePublished - Dec 18 2017

Keywords

  • Blood pressure
  • Chronic burden
  • Depression
  • Gene-by-environment interaction
  • Genetics
  • Hypertension
  • Non-burden test
  • Psychosocial factors
  • Socioeconomic status

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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