TY - JOUR
T1 - Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study
AU - Scuteri, Angelo
AU - Morrell, Christopher H.
AU - Orru', Marco
AU - Alghatrif, Majid
AU - Saba, Pier Sergio
AU - Terracciano, Antonio
AU - Ferreli, Liana Anna Pina
AU - Loi, Francesco
AU - Marongiu, Michele
AU - Pilia, Maria Grazia
AU - Delitala, Alessandro
AU - Tarasov, Kirill V.
AU - Schlessinger, David
AU - Ganau, Antonello
AU - Cucca, Francesco
AU - Lakatta, Edward G.
N1 - Publisher Copyright:
© 2016 Published by Elsevier Ireland Ltd.
PY - 2016/8/15
Y1 - 2016/8/15
N2 - Background: There is no definite consensus on the CV burden associated to Masked hypertension (MH) or White Coat Hypertension (WCH)-conditions that can be detected by out-of-office blood pressure measurements (24 hour Ambulatory Blood Pressure Monitoring, 24 h ABPM). Methods: We investigated the association of WCH and MH with arterial aging, indexed by a range of parameters of large artery structure and function in 2962 subjects, taking no antihypertensive medications, who are participating in a large community-based population of both men and women over a broad age range (14-102 years). Results: The overall prevalence of WCH was 9.5% and was 5.0% for MH, with 54.9% of subjects classified as true normotensive and 30.6% as true hypertensive. Both WCH and MH were associated with a stiffer aorta, a less distensible and thicker common carotid artery, and greater central BP than true normotensive subjects. Notably, the profile of arterial alterations in WCH and MH did not significantly differ from what was observed in true hypertensive subjects. The arterial changes accompanying WCH and MH differed in men and women, with women showing a greater tendency towards concentric remodeling, greater parietal wall stress, and PWV than men. Conclusion: Both WCH, and MH are associatedwith early arterial aging, and therefore, neither can be regarded as innocent conditions. Future studies are required to establish whether measurement of arterial aging parameters in subjects with WCH or MHwill identify subjects at higher risk of CV events and cognitive impairment, who may require more clinical attention and pharmacological intervention.
AB - Background: There is no definite consensus on the CV burden associated to Masked hypertension (MH) or White Coat Hypertension (WCH)-conditions that can be detected by out-of-office blood pressure measurements (24 hour Ambulatory Blood Pressure Monitoring, 24 h ABPM). Methods: We investigated the association of WCH and MH with arterial aging, indexed by a range of parameters of large artery structure and function in 2962 subjects, taking no antihypertensive medications, who are participating in a large community-based population of both men and women over a broad age range (14-102 years). Results: The overall prevalence of WCH was 9.5% and was 5.0% for MH, with 54.9% of subjects classified as true normotensive and 30.6% as true hypertensive. Both WCH and MH were associated with a stiffer aorta, a less distensible and thicker common carotid artery, and greater central BP than true normotensive subjects. Notably, the profile of arterial alterations in WCH and MH did not significantly differ from what was observed in true hypertensive subjects. The arterial changes accompanying WCH and MH differed in men and women, with women showing a greater tendency towards concentric remodeling, greater parietal wall stress, and PWV than men. Conclusion: Both WCH, and MH are associatedwith early arterial aging, and therefore, neither can be regarded as innocent conditions. Future studies are required to establish whether measurement of arterial aging parameters in subjects with WCH or MHwill identify subjects at higher risk of CV events and cognitive impairment, who may require more clinical attention and pharmacological intervention.
KW - 24 hour blood pressure monitoring
KW - Arterial aging
KW - Arterial stiffness
KW - Carotid thickness
KW - Masked hypertension
KW - Pulse wave velocity
KW - White coat hypertension
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U2 - 10.1016/j.ijcard.2016.04.172
DO - 10.1016/j.ijcard.2016.04.172
M3 - Article
C2 - 27179214
AN - SCOPUS:84966415679
SN - 0167-5273
VL - 217
SP - 92
EP - 98
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -