Gender-specific physical symptom biology in heart failure

Christopher S. Lee, Shirin O. Hiatt, Quin E. Denfeld, Christopher V. Chien, James O. Mudd, Jill M. Gelow

Research output: Contribution to journalArticle

Abstract

Background: There are several gender differences that may help explain the link between biology and symptoms in heart failure (HF). Objective: The aim of this study was to examine gender-specific relationships between objective measures of HF severity and physical symptoms. Methods: Detailed clinical data, including left ventricular ejection fraction and left ventricular internal end-diastolic diameter, and HF-specific physical symptoms were collected as part of a prospective cohort study. Gender interaction terms were tested in linear regression models of physical symptoms. Results: The sample (101 women and 101 men) averaged 57 years of age and most participants (60%) had class III/IV HF. Larger left ventricle size was associated with better physical symptoms for women and worse physical symptoms for men. Conclusion: Decreased ventricular compliance may result in worse physical HF symptoms for women and dilation of the ventricle may be a greater progenitor of symptoms for men with HF.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalThe Journal of cardiovascular nursing
Volume30
Issue number6
DOIs
StatePublished - Oct 9 2015
Externally publishedYes

Fingerprint

Heart Failure
Linear Models
Diastolic Heart Failure
Stroke Volume
Compliance
Heart Ventricles
Dilatation
Cohort Studies
Prospective Studies

Keywords

  • Gender
  • Heart Failure
  • Symptoms

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, C. S., Hiatt, S. O., Denfeld, Q. E., Chien, C. V., Mudd, J. O., & Gelow, J. M. (2015). Gender-specific physical symptom biology in heart failure. The Journal of cardiovascular nursing, 30(6), 517-521. https://doi.org/10.1097/JCN.0000000000000191

Gender-specific physical symptom biology in heart failure. / Lee, Christopher S.; Hiatt, Shirin O.; Denfeld, Quin E.; Chien, Christopher V.; Mudd, James O.; Gelow, Jill M.

In: The Journal of cardiovascular nursing, Vol. 30, No. 6, 09.10.2015, p. 517-521.

Research output: Contribution to journalArticle

Lee, CS, Hiatt, SO, Denfeld, QE, Chien, CV, Mudd, JO & Gelow, JM 2015, 'Gender-specific physical symptom biology in heart failure', The Journal of cardiovascular nursing, vol. 30, no. 6, pp. 517-521. https://doi.org/10.1097/JCN.0000000000000191
Lee, Christopher S. ; Hiatt, Shirin O. ; Denfeld, Quin E. ; Chien, Christopher V. ; Mudd, James O. ; Gelow, Jill M. / Gender-specific physical symptom biology in heart failure. In: The Journal of cardiovascular nursing. 2015 ; Vol. 30, No. 6. pp. 517-521.
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