Gender-specific physical symptom biology in heart failure

Christopher S. Lee, Shirin O. Hiatt, Quin E. Denfeld, Christopher V. Chien, James O. Mudd, Jill M. Gelow

Research output: Contribution to journalArticle


Background: There are several gender differences that may help explain the link between biology and symptoms in heart failure (HF). Objective: The aim of this study was to examine gender-specific relationships between objective measures of HF severity and physical symptoms. Methods: Detailed clinical data, including left ventricular ejection fraction and left ventricular internal end-diastolic diameter, and HF-specific physical symptoms were collected as part of a prospective cohort study. Gender interaction terms were tested in linear regression models of physical symptoms. Results: The sample (101 women and 101 men) averaged 57 years of age and most participants (60%) had class III/IV HF. Larger left ventricle size was associated with better physical symptoms for women and worse physical symptoms for men. Conclusion: Decreased ventricular compliance may result in worse physical HF symptoms for women and dilation of the ventricle may be a greater progenitor of symptoms for men with HF.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalThe Journal of cardiovascular nursing
Issue number6
Publication statusPublished - Oct 9 2015
Externally publishedYes



  • Gender
  • Heart Failure
  • Symptoms

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, C. S., Hiatt, S. O., Denfeld, Q. E., Chien, C. V., Mudd, J. O., & Gelow, J. M. (2015). Gender-specific physical symptom biology in heart failure. The Journal of cardiovascular nursing, 30(6), 517-521.