Gender-specific aging effects on the serotonin 1A receptor

Carolyn Cidis Meltzer; Wayne C. Drevets; Julie C. Price; Chester A. Mathis; Brian Lopresti; Phil J. Greer; Victor L. Villemagne; Daniel Holt; N. Scott Mason; Patricia R. Houck; Charles F. Reynolds; Steven T. DeKosky

doi:10.1016/S0006-8993(00)03211-X

Gender-specific aging effects on the serotonin 1A receptor

Carolyn Cidis Meltzer, Wayne C. Drevets, Julie C. Price, Chester A. Mathis, Brian Lopresti, Phil J. Greer, Victor L. Villemagne, Daniel Holt, N. Scott Mason, Patricia R. Houck, Charles F. Reynolds, Steven T. DeKosky

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [¹¹C-carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [¹¹C-carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.

Original language	English (US)
Pages (from-to)	9-17
Number of pages	9
Journal	Brain research
Volume	895
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)03211-X
State	Published - Mar 23 2001
Externally published	Yes

Keywords

Aging
Emission tomography
Serotonin receptor
Sex

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)03211-X

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title = "Gender-specific aging effects on the serotonin 1A receptor",

abstract = "The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [11C-carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [11C-carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.",

keywords = "Aging, Emission tomography, Serotonin receptor, Sex",

author = "Meltzer, {Carolyn Cidis} and Drevets, {Wayne C.} and Price, {Julie C.} and Mathis, {Chester A.} and Brian Lopresti and Greer, {Phil J.} and Villemagne, {Victor L.} and Daniel Holt and Mason, {N. Scott} and Houck, {Patricia R.} and Reynolds, {Charles F.} and DeKosky, {Steven T.}",

note = "Funding Information: This work was supported by PHS grants MH52247 (Intervention Research Center for Late-Life Mood Disorders), AG05133 (Alzheimer{\textquoteright}s Disease Research Center), MH01210, MH51137, MH37869, and MH00295. We also thank Barbara Tracey, Michelle Zmuda, Ann Black, and Peggy Anderson for their contributions to this work.",

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doi = "10.1016/S0006-8993(00)03211-X",

language = "English (US)",

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AU - Meltzer, Carolyn Cidis

AU - Drevets, Wayne C.

AU - Price, Julie C.

AU - Mathis, Chester A.

AU - Lopresti, Brian

AU - Greer, Phil J.

AU - Villemagne, Victor L.

AU - Holt, Daniel

AU - Mason, N. Scott

AU - Houck, Patricia R.

AU - Reynolds, Charles F.

AU - DeKosky, Steven T.

N1 - Funding Information: This work was supported by PHS grants MH52247 (Intervention Research Center for Late-Life Mood Disorders), AG05133 (Alzheimer’s Disease Research Center), MH01210, MH51137, MH37869, and MH00295. We also thank Barbara Tracey, Michelle Zmuda, Ann Black, and Peggy Anderson for their contributions to this work.

PY - 2001/3/23

Y1 - 2001/3/23

N2 - The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [11C-carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [11C-carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.

AB - The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [11C-carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [11C-carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.

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KW - Serotonin receptor

KW - Sex

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Gender-specific aging effects on the serotonin 1A receptor

Abstract

Keywords

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