Gender influence on cognitive function after cardiac operation

Charles W. Hogue, Rema Lillie, Tamara Hershey, Stanley Birge, Abdullah M. Nassief, Betsy Thomas, Kenneth E. Freedland

Research output: Contribution to journalArticle

Abstract

Background. Women are at higher risk than men for stroke after cardiac operation. The purpose of this study was to evaluate for gender influences on the more common postoperative neurologic complication, cognitive dysfunction. Methods. A standard battery of neuropsychological tests was administered to 117 patients (79 men and 38 women) the day before and again 4 to 6 weeks after cardiac operation. The battery assessed a broad array of cognitive domains, including attention, memory, executive function, and psychomotor processing speed. Analysis was performed only on patients with data from both testing sessions. Data were analyzed to assess for a dichotomous definition of postoperative cognitive impairment and to evaluate for factors influencing test results for specific cognitive domains. Results. The frequency of one standard deviation decline on two or more cognitive tests compared with preoperative results (women, 10.7% versus men, 9.9%; p = 0.527), no decline, or one standard deviation improvement on each test postoperatively was no different between genders. After adjusting for age, gender, preexisting medical conditions, level of attained education, preoperative cognitive tests results, type of operation, and duration of cardiopulmonary bypass, female gender was independently associated with poorer performance postoperatively on visuospatial tasks. Other variables significantly related to postoperative cognitive function varied among the specific cognitive domains. Conclusions. These data suggest that, although the frequency of cognitive dysfunction after cardiac operation is similar for women and men, women appear more likely to suffer injury to brain areas subserving visuo-spatial processing. Risk factors for postoperative cognitive impairment vary depending on cognitive domain, suggesting multiple etiologies for this form of perioperative neurologic injury.

Original languageEnglish (US)
Pages (from-to)1119-1125
Number of pages7
JournalAnnals of Thoracic Surgery
Volume76
Issue number4
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

Fingerprint

Cognition
Nervous System Trauma
Preexisting Condition Coverage
Neuropsychological Tests
Executive Function
Cardiopulmonary Bypass
Brain Injuries
Nervous System
Stroke
Education
Cognitive Dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Hogue, C. W., Lillie, R., Hershey, T., Birge, S., Nassief, A. M., Thomas, B., & Freedland, K. E. (2003). Gender influence on cognitive function after cardiac operation. Annals of Thoracic Surgery, 76(4), 1119-1125. https://doi.org/10.1016/S0003-4975(03)00817-8

Gender influence on cognitive function after cardiac operation. / Hogue, Charles W.; Lillie, Rema; Hershey, Tamara; Birge, Stanley; Nassief, Abdullah M.; Thomas, Betsy; Freedland, Kenneth E.

In: Annals of Thoracic Surgery, Vol. 76, No. 4, 01.10.2003, p. 1119-1125.

Research output: Contribution to journalArticle

Hogue, CW, Lillie, R, Hershey, T, Birge, S, Nassief, AM, Thomas, B & Freedland, KE 2003, 'Gender influence on cognitive function after cardiac operation', Annals of Thoracic Surgery, vol. 76, no. 4, pp. 1119-1125. https://doi.org/10.1016/S0003-4975(03)00817-8
Hogue CW, Lillie R, Hershey T, Birge S, Nassief AM, Thomas B et al. Gender influence on cognitive function after cardiac operation. Annals of Thoracic Surgery. 2003 Oct 1;76(4):1119-1125. https://doi.org/10.1016/S0003-4975(03)00817-8
Hogue, Charles W. ; Lillie, Rema ; Hershey, Tamara ; Birge, Stanley ; Nassief, Abdullah M. ; Thomas, Betsy ; Freedland, Kenneth E. / Gender influence on cognitive function after cardiac operation. In: Annals of Thoracic Surgery. 2003 ; Vol. 76, No. 4. pp. 1119-1125.
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