TY - JOUR
T1 - Gender differences in symptomatic profiles of depression
T2 - Results from the São Paulo Megacity Mental Health Survey
AU - Alexandrino-Silva, Clóvis
AU - Wang, Yuan Pang
AU - Carmen Viana, Maria
AU - Bulhões, Rodrigo S.
AU - Martins, Sílvia S.
AU - Andrade, Laura Helena
N1 - Funding Information:
The São Paulo Megacity Mental Health Survey was funded by the State of São Paulo Research Foundation, Brazil (FAPESP Grant 03/00204-3, URL: http://www.fapesp.br/materia/176/projeto-tematico/projeto-tematico.htm )
PY - 2013/5
Y1 - 2013/5
N2 - Background: Few studies have investigated symptomatic subtypes of depression and their correlates by gender. Methods: Data are from the São Paulo Megacity Mental Health Survey. Symptom profiles of 1207 subjects (864 women; 343 men) based upon symptoms of the worst depressive episode in lifetime were examined through latent class analysis. Correlates of gender-specific latent classes were analyzed by logistic regression. Results: For both men and women, a 3-class model was the best solution. A mild class was found in both genders (41.1% in women; 40.1% in men). Gender differences appeared in the most symptomatic classes. In women, they were labeled melancholic (39.3%) and atypical (19.5%), differing among each other in somatic/vegetative symptoms. The melancholic class presented inhibition and eating/sleeping symptoms in the direction of decreasing, whereas the atypical class had increased appetite/weight, and hypersomnia. For men, symptoms that differentiate the two most symptomatic classes were related to psychomotor activity: a melancholic/psychomotor retarded (40.4%) and agitated depression (19.6%). The highest between-class proportion of agitation and racing thoughts was found among men in the agitated class, with similarity to bipolar mixed state. Limitations: Analyses were restricted to those who endorsed questions about their worst lifetime depressive episode; the standardized assessment by lay interviewers; the small male sample size. Conclusions: The construct of depression of current classifications is heterogeneous at the symptom level, where gender different subtypes can be identified. These symptom profiles have potential implications for the nosology and the therapeutics of depression.
AB - Background: Few studies have investigated symptomatic subtypes of depression and their correlates by gender. Methods: Data are from the São Paulo Megacity Mental Health Survey. Symptom profiles of 1207 subjects (864 women; 343 men) based upon symptoms of the worst depressive episode in lifetime were examined through latent class analysis. Correlates of gender-specific latent classes were analyzed by logistic regression. Results: For both men and women, a 3-class model was the best solution. A mild class was found in both genders (41.1% in women; 40.1% in men). Gender differences appeared in the most symptomatic classes. In women, they were labeled melancholic (39.3%) and atypical (19.5%), differing among each other in somatic/vegetative symptoms. The melancholic class presented inhibition and eating/sleeping symptoms in the direction of decreasing, whereas the atypical class had increased appetite/weight, and hypersomnia. For men, symptoms that differentiate the two most symptomatic classes were related to psychomotor activity: a melancholic/psychomotor retarded (40.4%) and agitated depression (19.6%). The highest between-class proportion of agitation and racing thoughts was found among men in the agitated class, with similarity to bipolar mixed state. Limitations: Analyses were restricted to those who endorsed questions about their worst lifetime depressive episode; the standardized assessment by lay interviewers; the small male sample size. Conclusions: The construct of depression of current classifications is heterogeneous at the symptom level, where gender different subtypes can be identified. These symptom profiles have potential implications for the nosology and the therapeutics of depression.
KW - Depression
KW - Depressive symptoms
KW - Gender differences
KW - Mental disorders
KW - Population-based study
KW - Subtypes of depression
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U2 - 10.1016/j.jad.2012.11.041
DO - 10.1016/j.jad.2012.11.041
M3 - Article
C2 - 23246363
AN - SCOPUS:84875369813
SN - 0165-0327
VL - 147
SP - 355
EP - 364
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-3
ER -