Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance

Deborah H. Kwon, Carmel M. Halley, Zoran B. Popovic, Thomas P. Carrigan, Victoria Zysek, Randolph Setser, Paul Schoenhagen, Scott D. Flamm, Randall C. Starling, Milind Y. Desai

Research output: Contribution to journalArticlepeer-review

Abstract

Aims We sought to determine the association between myocardial scarring, gender, and survival in patients with significant coronary artery disease (CAD) and severe systolic left ventricular (LV) dysfunction using delayed hyper-enhancement cardiac magnetic resonance imaging (DHE-CMR).Methods and resultsWe studied 339 patients (24% women, mean age 65 ± 11 years) referred for assessment of myocardial viability by DHE-CMR. Scar was defined as myocardium with an intensity >2 SD above viable myocardium. Left ventricular scar (defined as a percentage of total LV myocardium), LV volumes, risk factors, cardiac transplantation (CTx), and all-cause mortality were recorded. There were 84 deaths and five CTx over 3.7 ± 1.6 years (median 4 years, interquartile range 2.6-4.9 years). Left ventricular ejection fraction (LVEF) in men was only slightly different from women (23% ± 9 vs. 25% ± 10, P = 0.05), whereas mean scar % was similar in both groups (32 ± 21 vs. 29 ± 20, P = 0.3). On univariable survival analysis, age [hazard ratio, HR, 1.03 (1.01-1.05), P = 0.002], female gender [HR 2.02 (1.31-3.12), P = 0.001], and scar % [HR 1.01 (1.003-1.02), P = 0.009] predicted outcomes; and also on multivariable analysis (χ2 32, P <0.0001). Women with scar greater than the median had more events, compared with men with or without a high scar burden (log-rank P <0.001).Conclusion In patients with CAD and severely reduced LVEF, women have worse outcomes than men, irrespective of myocardial scar burden.

Original languageEnglish (US)
Pages (from-to)937-944
Number of pages8
JournalEuropean Journal of Heart Failure
Volume11
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

Keywords

  • Delayed hyper-enhancement CMR
  • Gender differences
  • Outcomes
  • Severe left ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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