Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

H. Pitchekian-Haiabi, S. Kirn, A. Mackenzie-Graham, H. F. McFarland, O. S. Raine, R. R. Voskuhl

Research output: Contribution to journalArticle

Abstract

Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number6
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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    Pitchekian-Haiabi, H., Kirn, S., Mackenzie-Graham, A., McFarland, H. F., Raine, O. S., & Voskuhl, R. R. (1996). Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis. FASEB Journal, 10(6).