Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

H. Pitchekian-Haiabi; S. Kirn; A. Mackenzie-Graham; H. F. McFarland; O. S. Raine; R. R. Voskuhl

Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

H. Pitchekian-Haiabi, S. Kirn, A. Mackenzie-Graham, H. F. McFarland, O. S. Raine, R. R. Voskuhl

Research output: Contribution to journal › Article › peer-review

Abstract

Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

Original language	English (US)
Journal	FASEB Journal
Volume	10
Issue number	6
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
Biochemistry
Cell Biology

Cite this

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AU - Pitchekian-Haiabi, H.

AU - Kirn, S.

AU - Mackenzie-Graham, A.

AU - McFarland, H. F.

AU - Raine, O. S.

AU - Voskuhl, R. R.

PY - 1996

Y1 - 1996

N2 - Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

AB - Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

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Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

Abstract

ASJC Scopus subject areas

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