Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

H. Pitchekian-Haiabi, S. Kirn, A. Mackenzie-Graham, H. F. McFarland, O. S. Raine, R. R. Voskuhl

Research output: Contribution to journalArticle

Abstract

Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number6
StatePublished - 1996
Externally publishedYes

Fingerprint

T-cells
sclerosis
Demyelinating Diseases
gender differences
Multiple Sclerosis
Myelin Basic Protein
Autoimmune Experimental Encephalomyelitis
mice
encephalitis
Animals
T-lymphocytes
T-Lymphocytes
Adoptive Transfer
Animal Models
animal models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Pitchekian-Haiabi, H., Kirn, S., Mackenzie-Graham, A., McFarland, H. F., Raine, O. S., & Voskuhl, R. R. (1996). Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis. FASEB Journal, 10(6).

Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis. / Pitchekian-Haiabi, H.; Kirn, S.; Mackenzie-Graham, A.; McFarland, H. F.; Raine, O. S.; Voskuhl, R. R.

In: FASEB Journal, Vol. 10, No. 6, 1996.

Research output: Contribution to journalArticle

Pitchekian-Haiabi, H, Kirn, S, Mackenzie-Graham, A, McFarland, HF, Raine, OS & Voskuhl, RR 1996, 'Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis', FASEB Journal, vol. 10, no. 6.
Pitchekian-Haiabi H, Kirn S, Mackenzie-Graham A, McFarland HF, Raine OS, Voskuhl RR. Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis. FASEB Journal. 1996;10(6).
Pitchekian-Haiabi, H. ; Kirn, S. ; Mackenzie-Graham, A. ; McFarland, H. F. ; Raine, O. S. ; Voskuhl, R. R. / Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis. In: FASEB Journal. 1996 ; Vol. 10, No. 6.
@article{f38612c4180647c085a36da41d301471,
title = "Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis",
abstract = "Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p",
author = "H. Pitchekian-Haiabi and S. Kirn and A. Mackenzie-Graham and McFarland, {H. F.} and Raine, {O. S.} and Voskuhl, {R. R.}",
year = "1996",
language = "English (US)",
volume = "10",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "6",

}

TY - JOUR

T1 - Gender differences in autoimmune demyelination in the mouse; implications for multiple sclerosis

AU - Pitchekian-Haiabi, H.

AU - Kirn, S.

AU - Mackenzie-Graham, A.

AU - McFarland, H. F.

AU - Raine, O. S.

AU - Voskuhl, R. R.

PY - 1996

Y1 - 1996

N2 - Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

AB - Gender differences in adoptive experimental allergic encephalomyelitis (EAE) were examined in the SJL to characterize an animal model ideal for the study of gender differences in multiple sclerosis (MS). First, the SJL strain was shown to lack the development of anti-syngenic HY specific responses in females thereby permitting intergender adoptive transfers of T lymphocytes during EAE induction. Then, when myelin basic protein (MBP) specific T cells derived from females were adoptively transferred into female and male recipients, female recipients demonstrated a more rapid onset of disease (p=.01) and a greater mean clinical score (p

UR - http://www.scopus.com/inward/record.url?scp=10144223866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10144223866&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:10144223866

VL - 10

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 6

ER -