Gender dependence for a subset of the low-abundance signaling proteome in human platelets

Harvey B. Pollard, Ofer Eidelman, Catherine Jozwik, Wei Huang, Meera Srivastava, Stephen W. Rothwell, David M. Jacobowitz, Xiaoduo Ji, Xiuying Zhang, William Guggino, Jerry Wright, Jeffrey Kiefer, Cara Olsen, Nima Adimi, Gregory P. Mueller

Research output: Contribution to journalArticle

Abstract

The incidence of cardiovascular diseases is ten-times higher in males than females, although the biological basis for this gender disparity is not known. However, based on the fact that antiplatelet drugs are the mainstay for prevention and therapy, we hypothesized that the signaling proteomes in platelets from normal male donors might be more activated than platelets from normal female donors. We report here that platelets from male donors express significantly higher levels of signaling cascade proteins than platelets from female donors. In silico connectivity analysis shows that the 24 major hubs in platelets from male donors focus on pathways associated with megakaryocytic expansion and platelet activation. By contrast, the 11 major hubs in platelets from female donors were found to be either negative or neutral for platelet-relevant processes. The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease.

Original languageEnglish (US)
Article number164906
JournalHuman Genomics and Proteomics
DOIs
StatePublished - May 24 2010

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

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    Pollard, H. B., Eidelman, O., Jozwik, C., Huang, W., Srivastava, M., Rothwell, S. W., Jacobowitz, D. M., Ji, X., Zhang, X., Guggino, W., Wright, J., Kiefer, J., Olsen, C., Adimi, N., & Mueller, G. P. (2010). Gender dependence for a subset of the low-abundance signaling proteome in human platelets. Human Genomics and Proteomics, [164906]. https://doi.org/10.4061/2010/164906