@article{9313c65ae752492bb7982a46edbc0091,
title = "GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation",
abstract = "Communication between neurons and oligodendroglial cells regulates oligodendrocyte development. Here, Choi et al. show that the six-transmembrane GPI-anchor-cleaving enzyme GDE2 stimulates canonical Wnt signaling in neurons to release soluble factors, such as phosphacan, to promote oligodendrocyte maturation.",
keywords = "GDE2, Wnt signaling, myelination, oligodendrocyte maturation, phosphacan",
author = "Choi, {Bo Ran} and Clinton Cave and Na, {Chan Hyun} and Shanthini Sockanathan",
note = "Funding Information: We thank C. Wladyka and Y. Li for technical assistance; Drs. D. Bergles, P. Calabresi, and S. Bouyain and the Sockanathan lab for discussions; L. Florea for bioinformatics; Drs. J. Nathans (Rosa26 Tcf/Lef H2B-EGFP), M. Taketo (Ctnnb1flex3/+), K. Nave (Nex:Cre), and D. Bergles (PDGFαR-CreER) for mice; and the Multiphoton Imaging Core of the Johns Hopkins P30 Center for Neuroscience Research ( NS050274 ). B.-R.C. was supported by a Fulbright Graduate Study Award (Science and Engineering). This work was supported by the National Institutes of Health (grant R01NS046336 to S.S.). Funding Information: We thank C. Wladyka and Y. Li for technical assistance; Drs. D. Bergles, P. Calabresi, and S. Bouyain and the Sockanathan lab for discussions; L. Florea for bioinformatics; Drs. J. Nathans (Rosa26 Tcf/Lef H2B-EGFP), M. Taketo (Ctnnb1flex3/+), K. Nave (Nex:Cre), and D. Bergles (PDGF?R-CreER) for mice; and the Multiphoton Imaging Core of the Johns Hopkins P30 Center for Neuroscience Research (NS050274). B.-R.C. was supported by a Fulbright Graduate Study Award (Science and Engineering). This work was supported by the National Institutes of Health (grant R01NS046336 to S.S.). B.C. and S.S. conceived the project. B.C. performed all experiments except for RNA-seq (C.C.) and mass spectrometry studies (C.H.N.). B.C. and S.S. designed the experiments, interpreted the results, compiled and archived data, and wrote the manuscript. All authors read, edited, and contributed to the final version of the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = may,
day = "5",
doi = "10.1016/j.celrep.2020.107540",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}