GCH1 haplotypes and cardiovascular risk in HIV

James E. Slaven; David W. Haas; Ziyue Liu; James H. Stein; Todd T. Brown; Samir K. Gupta

doi:10.1097/QAD.0000000000002263

GCH1 haplotypes and cardiovascular risk in HIV

James E. Slaven, David W. Haas, Ziyue Liu, James H. Stein, Todd T. Brown, Samir K. Gupta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.

Original language	English (US)
Pages (from-to)	1669-1671
Number of pages	3
Journal	AIDS
Volume	33
Issue number	10
DOIs	https://doi.org/10.1097/QAD.0000000000002263
State	Published - Aug 1 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000002263

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abstract = "Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.",

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AU - Slaven, James E.

AU - Haas, David W.

AU - Liu, Ziyue

AU - Stein, James H.

AU - Brown, Todd T.

AU - Gupta, Samir K.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.

AB - Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.

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JO - AIDS

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GCH1 haplotypes and cardiovascular risk in HIV

Abstract

ASJC Scopus subject areas

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