GCH1 haplotypes and cardiovascular risk in HIV

James E. Slaven, David W. Haas, Ziyue Liu, James H. Stein, Todd T. Brown, Samir K. Gupta

Research output: Contribution to journalArticle

Abstract

Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.

Original languageEnglish (US)
Pages (from-to)1669-1671
Number of pages3
JournalAIDS
Volume33
Issue number10
DOIs
StatePublished - Aug 1 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T., & Gupta, S. K. (2019). GCH1 haplotypes and cardiovascular risk in HIV. AIDS, 33(10), 1669-1671. https://doi.org/10.1097/QAD.0000000000002263