Abstract
Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1669-1671 |
| Number of pages | 3 |
| Journal | AIDS |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| State | Published - Aug 1 2019 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases
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Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T., & Gupta, S. K. (2019). GCH1 haplotypes and cardiovascular risk in HIV. AIDS, 33(10), 1669-1671. https://doi.org/10.1097/QAD.0000000000002263