TY - JOUR
T1 - GB virus infection
T2 - a silent anti-HIV panacea within?
AU - Shankar, Esaki Muthu
AU - Solomon, Sunil Suhas
AU - Vignesh, Ramachandran
AU - Murugavel, Kailapuri G.
AU - Sundaram, Muthu
AU - Solomon, Suniti
AU - Balakrishnan, Pachamuthu
AU - Kumarasamy, Nagalingeswaran
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/12
Y1 - 2008/12
N2 - The GB virus (GBV)/hepatitis G virus is a member of the Flaviviridae family and belongs to the hepatitis group of viruses transmitted parenterally, common among intravenous drug users. The strong association between GBV and HIV infection suggests that the two viruses may share similar epidemiological and transmission features. GBV infection is widely believed to prolong HIV disease progression as well as decreasing the HIV viral load and increasing the CD4+ T-cell level. GBV-driven anti-E2 antibodies have been shown to inhibit HIV replication in vitro. Preliminary studies also suggest that GBV infection of peripheral blood mononuclear cells leads to increased production of β-chemokines, which may explain the in vitro inhibitory effects and warrants further studies. With sufficient knowledge of resistance patterns studied in tropical south India, researchers are now keen to study the competitive interactions between GBV-induced chemokines and HIV ligands to bind CCR5.
AB - The GB virus (GBV)/hepatitis G virus is a member of the Flaviviridae family and belongs to the hepatitis group of viruses transmitted parenterally, common among intravenous drug users. The strong association between GBV and HIV infection suggests that the two viruses may share similar epidemiological and transmission features. GBV infection is widely believed to prolong HIV disease progression as well as decreasing the HIV viral load and increasing the CD4+ T-cell level. GBV-driven anti-E2 antibodies have been shown to inhibit HIV replication in vitro. Preliminary studies also suggest that GBV infection of peripheral blood mononuclear cells leads to increased production of β-chemokines, which may explain the in vitro inhibitory effects and warrants further studies. With sufficient knowledge of resistance patterns studied in tropical south India, researchers are now keen to study the competitive interactions between GBV-induced chemokines and HIV ligands to bind CCR5.
KW - Disease progression
KW - GB virus
KW - HIV
KW - Hepatitis
KW - Intravenous drug users
KW - Transmission
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U2 - 10.1016/j.trstmh.2008.04.034
DO - 10.1016/j.trstmh.2008.04.034
M3 - Review article
C2 - 18513775
AN - SCOPUS:54949158288
SN - 0035-9203
VL - 102
SP - 1176
EP - 1180
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 12
ER -