GB virus C (GBV-C) infection in hepatitis C virus (HCV) seropositive women with or at risk for HIV infection e114467

Jason T. Blackard, Gang Ma, Jeffrey A. Welge, Caroline C. King, Lynn E. Taylor, Kenneth H. Mayer, Robert S. Klein, David D. Celentano, Jack D. Sobel, Denise J. Jamieson, Lytt Gardner

Research output: Contribution to journalArticlepeer-review

Abstract

Results: 438 hepatitis C virus (HCV) seropositive women, including 306 HIVinfected and 132 HIV-uninfected women, from the HIV Epidemiologic Research Study were evaluated for GBV-C RNA. 347 (79.2%) women were GBV-C RNA negative, while 91 (20.8%) were GBV-C RNA positive. GBV-C positive women were younger than GBV-C negative women. Among 306 HIV-infected women, 70 (22.9%) women were HIV/GBV-C co-infected. Among HIV-infected women, the only significant difference between GBV-negative and GBV-positive women was age (mean 38.4 vs. 35.1 years; p<0.001). Median baseline CD4 cell counts and plasma HIV RNA levels were similar. The GBV-C genotypes were 1 (n531; 44.3%), 2 (n536; 51.4%), and 3 (n53; 4.3%). The distribution of GBV-C genotypes in coinfected women differed significantly by race/ethnicity. However, median CD4 cell counts and log10 HIV RNA levels did not differ by GBV-C genotype. GBV-C incidence was 2.7% over a median follow-up of 2.9 (IQR: 1.5, 4.9) years, while GBV-C clearance was 35.7% over a median follow-up of 2.44 (1.4, 3.5) years. 4 women switched genotypes.

Background: GB virus C (GBV-C) may have a beneficial impact on HIV disease progression; however, the epidemiologic characteristics of this virus are not well characterized. Behavioral factors and gender may lead to differential rates of GBVC infection; yet, studies have rarely addressed GBV-C infections in women or racial/ethnic minorities. Therefore, we evaluated GBV-C RNA prevalence and genotype distribution in a large prospective study of high-risk women in the US.

Conclusions: Age, injection drug use, a history of sex for money or drugs, and number of recent male sex partners were associated with GBV-C infection among all women in this analysis. However, CD4 cell count and HIV viral load of HIV/HCV/ GBV-C co-infected women were not different although race was associated with GBV-C genotype.

Original languageEnglish (US)
Article numbere114467
JournalPloS one
Volume9
Issue number12
DOIs
StatePublished - Dec 10 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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