Gates of Janus: cystic fibrosis and diarrhea

Sandra E. Guggino

Research output: Contribution to journalComment/debatepeer-review

Abstract

Heat-stable enterotoxin, produced by Escherichia coli, binds to particulate guanylate cyclase to increase cyclic GMP in intestinal cells. This in turn stimulates the cyclic-GMP- or cyclic-AMP-dependent protein kinase, activating the same chloride channel that is defective in cystic fibrosis. It is possible that the relatively high prevalence of cystic fibrosis in humans results from its protective effect against diarrhea.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalTrends in Microbiology
Volume2
Issue number3
DOIs
StatePublished - Mar 1994

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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