Gated cardiac SPECT in rodents using a dedicated SPECT system: X-SPECT

T. Vandehei, J. Li, K. Iwata, B. E. Patt, G. Caravaglia, N. E. Hartsough, B. Hasegawa, Benjamin Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac scans are a standard of care for patients with suspected coronary artery occlusions and can assess perfusion and other physiological functions via the injection of radiotracers. In addition, correlated acquisition of nuclear images with electrocardiogram (ECG) signals can provide myocardial dynamics, which can be used to assess the wall motion of the heart. We have implemented this nuclear cardiology technique into a microSPECT/CT system, which provides sub-millimeter resolution in SPECT and co-registered high resolution CT anatomical maps. Radionuclide detection is synchronized with the R-wave of the cardiac cycle and separated into 16 time bins using an ECG monitor and triggering device for gating. Images were acquired with a 12.5×12.5 cm 2 small field of view pixilated Nal(Tl) detector, using a pinhole collimator. In this pilot study, rats (N=5) were injected with 99mTc-Sestamibi, a tracer of myocardium, and anesthetized for imaging. Reconstructed 4-D images (3D plus timing) were computed using an Ordered Subset Expectation Maximization (OSEM) algorithm. The measured perfusion, wall motion, and ejection fractions for the rats matched well with results reported by other researchers using alternative methods. This capability will provide a new and powerful tool to preclinical researchers for assessing cardiac function.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsF.P. Doty, R.C. Schirato, H.B. Barber, H. Roehrig
Pages165-170
Number of pages6
Volume5541
DOIs
StatePublished - 2004
EventPenetrating Radiation Systems and Applications VI - Denver, CO, United States
Duration: Aug 4 2004Aug 5 2004

Other

OtherPenetrating Radiation Systems and Applications VI
CountryUnited States
CityDenver, CO
Period8/4/048/5/04

Fingerprint

rodents
electrocardiography
Electrocardiography
rats
Rats
cardiology
Cardiology
myocardium
occlusion
Bins
pinholes
collimators
arteries
Set theory
Radioisotopes
ejection
radioactive isotopes
set theory
field of view
tracers

Keywords

  • CT
  • Dual-modality
  • Gated Cardiac Imaging
  • SPECT

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Vandehei, T., Li, J., Iwata, K., Patt, B. E., Caravaglia, G., Hartsough, N. E., ... Tsui, B. (2004). Gated cardiac SPECT in rodents using a dedicated SPECT system: X-SPECT. In F. P. Doty, R. C. Schirato, H. B. Barber, & H. Roehrig (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5541, pp. 165-170). [32] https://doi.org/10.1117/12.567145

Gated cardiac SPECT in rodents using a dedicated SPECT system : X-SPECT. / Vandehei, T.; Li, J.; Iwata, K.; Patt, B. E.; Caravaglia, G.; Hartsough, N. E.; Hasegawa, B.; Tsui, Benjamin.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / F.P. Doty; R.C. Schirato; H.B. Barber; H. Roehrig. Vol. 5541 2004. p. 165-170 32.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vandehei, T, Li, J, Iwata, K, Patt, BE, Caravaglia, G, Hartsough, NE, Hasegawa, B & Tsui, B 2004, Gated cardiac SPECT in rodents using a dedicated SPECT system: X-SPECT. in FP Doty, RC Schirato, HB Barber & H Roehrig (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5541, 32, pp. 165-170, Penetrating Radiation Systems and Applications VI, Denver, CO, United States, 8/4/04. https://doi.org/10.1117/12.567145
Vandehei T, Li J, Iwata K, Patt BE, Caravaglia G, Hartsough NE et al. Gated cardiac SPECT in rodents using a dedicated SPECT system: X-SPECT. In Doty FP, Schirato RC, Barber HB, Roehrig H, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5541. 2004. p. 165-170. 32 https://doi.org/10.1117/12.567145
Vandehei, T. ; Li, J. ; Iwata, K. ; Patt, B. E. ; Caravaglia, G. ; Hartsough, N. E. ; Hasegawa, B. ; Tsui, Benjamin. / Gated cardiac SPECT in rodents using a dedicated SPECT system : X-SPECT. Proceedings of SPIE - The International Society for Optical Engineering. editor / F.P. Doty ; R.C. Schirato ; H.B. Barber ; H. Roehrig. Vol. 5541 2004. pp. 165-170
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