GATA-3 expression in trophoblastic tissues: An immunohistochemical study of 445 cases, including diagnostic utility

Natalie Banet, Allen M. Gown, Ie Ming Shih, Qing Kay Li, Richard S Roden, Marisa R. Nucci, Liang Cheng, Christopher G. Przybycin, Niloofar Nasseri-Nik, Lee Shu Fune Wu, George J. Netto, Brigitte Maria Ronnett, Russell S Vang

Research output: Contribution to journalArticle

Abstract

Immunohistochemical expression of GATA-3 is seen predominantly in non-neoplastic bladder and breast epithelium and their respective carcinomas; however, data on expression in normal and lesional trophoblastic tissues are limited. Immunohistochemical staining for GATA-3 was assessed in a range of normal/lesional trophoblastic tissues and tumors in the differential diagnosis (n=445), including nonmolar products of conceptions/second and third trimester placentas/ectopic pregnancies, hydatidiform moles, placental site nodules, normal/exaggerated implantation sites, choriocarcinomas, epithelioid trophoblastic tumors, placental site trophoblastic tumors, atypical smooth muscle tumors (including leiomyosarcoma), and cervical and pulmonary squamous cell carcinomas. The extent of expression (0 to 4+) and intensity (weak to strong) were recorded. All cases with developing trophoblast/non-neoplastic trophoblastic proliferation and 81% of trophoblastic neoplasms were positive. Of all non-neoplastic trophoblast cell types, expression was observed in cytotrophoblast in 89% of cases, syncytiotrophoblast in 50%, intermediate trophoblast in 100%, and villous trophoblastic columns in 100%. Increasing gestational age was associated with a decrease in extent/intensity of expression in non-neoplastic cytotrophoblast and syncytiotrophoblast, whereas intermediate trophoblast maintained diffuse and strong expression from early to late gestation (P

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number1
StatePublished - Jan 20 2015

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Trophoblasts
Trophoblastic Neoplasms
Placental Site Trophoblastic Tumor
Smooth Muscle Tumor
Hydatidiform Mole
Choriocarcinoma
Leiomyosarcoma
Ectopic Pregnancy
Third Pregnancy Trimester
Second Pregnancy Trimester
Placenta
Gestational Age
Squamous Cell Carcinoma
Reference Values
Urinary Bladder
Breast
Differential Diagnosis
Epithelium
Staining and Labeling
Carcinoma

Keywords

  • Choriocarcinoma
  • GATA-3
  • Leiomyosarcoma
  • Squamous cell carcinoma
  • Trophoblast

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

GATA-3 expression in trophoblastic tissues : An immunohistochemical study of 445 cases, including diagnostic utility. / Banet, Natalie; Gown, Allen M.; Shih, Ie Ming; Li, Qing Kay; Roden, Richard S; Nucci, Marisa R.; Cheng, Liang; Przybycin, Christopher G.; Nasseri-Nik, Niloofar; Wu, Lee Shu Fune; Netto, George J.; Ronnett, Brigitte Maria; Vang, Russell S.

In: American Journal of Surgical Pathology, Vol. 39, No. 1, 20.01.2015, p. 101-108.

Research output: Contribution to journalArticle

Banet, Natalie ; Gown, Allen M. ; Shih, Ie Ming ; Li, Qing Kay ; Roden, Richard S ; Nucci, Marisa R. ; Cheng, Liang ; Przybycin, Christopher G. ; Nasseri-Nik, Niloofar ; Wu, Lee Shu Fune ; Netto, George J. ; Ronnett, Brigitte Maria ; Vang, Russell S. / GATA-3 expression in trophoblastic tissues : An immunohistochemical study of 445 cases, including diagnostic utility. In: American Journal of Surgical Pathology. 2015 ; Vol. 39, No. 1. pp. 101-108.
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AU - Roden, Richard S

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AU - Przybycin, Christopher G.

AU - Nasseri-Nik, Niloofar

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AU - Ronnett, Brigitte Maria

AU - Vang, Russell S

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