GATA-3 as a Marker of Hormone Response in Breast Cancer

Sandy H Fang, Yizhen Chen, Ronald J. Weigel

Research output: Contribution to journalArticle

Abstract

GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. The majority of breast cancers arise from luminal epithelial cells and hence GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-α (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. Here, we review the literature from the past 10 y on GATA-3 in normal and pathological states of the mammary gland. Conclusions from the literature are confirmed using meta-analyses performed by the Oncomine Research Platform.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalJournal of Surgical Research
Volume157
Issue number2
DOIs
StatePublished - Dec 2009
Externally publishedYes

Fingerprint

Human Mammary Glands
Hormones
Breast Neoplasms
Transcriptome
Estrogen Receptors
Embryonic Development
Meta-Analysis
Cell Differentiation
Transcription Factors
Central Nervous System
Biomarkers
Epithelial Cells
Kidney
Skin
Research
Genes
Therapeutics

Keywords

  • breast cancer
  • estrogen receptor
  • GATA-3
  • hormone response

ASJC Scopus subject areas

  • Surgery

Cite this

GATA-3 as a Marker of Hormone Response in Breast Cancer. / Fang, Sandy H; Chen, Yizhen; Weigel, Ronald J.

In: Journal of Surgical Research, Vol. 157, No. 2, 12.2009, p. 290-295.

Research output: Contribution to journalArticle

Fang, Sandy H ; Chen, Yizhen ; Weigel, Ronald J. / GATA-3 as a Marker of Hormone Response in Breast Cancer. In: Journal of Surgical Research. 2009 ; Vol. 157, No. 2. pp. 290-295.
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