Gastrointestinal tract spindle cell lesions-just like real estate, it's all about location

Lysandra Voltaggio, Elizabeth A. Montgomery

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies, whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GISTs) are generally centered in the muscularis propria. Schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery. Knowledge of the favored layer is even most important in interpreting colon biopsies, as many mesenschymal polyps are encountered in the colon. Although GISTs are among the most common mesenchymal lesions, we will concentrate our discussion on other mesenchymal lesions, some of which are in the differential diagnosis of GIST, and point out some diagnostic pitfalls, particularly in immunolabeling.

Original languageEnglish (US)
Pages (from-to)S47-S66
JournalModern Pathology
StatePublished - Jan 10 2015

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Gastrointestinal tract spindle cell lesions-just like real estate, it's all about location'. Together they form a unique fingerprint.

Cite this