Abstract
Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies, whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GISTs) are generally centered in the muscularis propria. Schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery. Knowledge of the favored layer is even most important in interpreting colon biopsies, as many mesenschymal polyps are encountered in the colon. Although GISTs are among the most common mesenchymal lesions, we will concentrate our discussion on other mesenchymal lesions, some of which are in the differential diagnosis of GIST, and point out some diagnostic pitfalls, particularly in immunolabeling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S47-S66 |
| Journal | Modern Pathology |
| Volume | 28 |
| DOIs | |
| State | Published - Jan 10 2015 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
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Gastrointestinal tract spindle cell lesions-just like real estate, it's all about location. / Voltaggio, Lysandra; Montgomery, Elizabeth A.
In: Modern Pathology, Vol. 28, 10.01.2015, p. S47-S66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastrointestinal tract spindle cell lesions-just like real estate, it's all about location
AU - Voltaggio, Lysandra
AU - Montgomery, Elizabeth A
PY - 2015/1/10
Y1 - 2015/1/10
N2 - Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies, whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GISTs) are generally centered in the muscularis propria. Schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery. Knowledge of the favored layer is even most important in interpreting colon biopsies, as many mesenschymal polyps are encountered in the colon. Although GISTs are among the most common mesenchymal lesions, we will concentrate our discussion on other mesenchymal lesions, some of which are in the differential diagnosis of GIST, and point out some diagnostic pitfalls, particularly in immunolabeling.
AB - Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies, whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GISTs) are generally centered in the muscularis propria. Schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery. Knowledge of the favored layer is even most important in interpreting colon biopsies, as many mesenschymal polyps are encountered in the colon. Although GISTs are among the most common mesenchymal lesions, we will concentrate our discussion on other mesenchymal lesions, some of which are in the differential diagnosis of GIST, and point out some diagnostic pitfalls, particularly in immunolabeling.
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UR - http://www.scopus.com/inward/citedby.url?scp=84920527987&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2014.126
DO - 10.1038/modpathol.2014.126
M3 - Article
C2 - 25560599
AN - SCOPUS:84920527987
VL - 28
SP - S47-S66
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
ER -