Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo

Arijit Ghosh, Ling Li, Liyi Xu, Ranjeet P. Dash, Neha Gupta, Jenny Lam, Qianru Jin, Venkata Akshintala, Gayatri Pahapale, Wangqu Liu, Anjishnu Sarkar, Rana Rais, David H. Gracias, Florin M. Selaru

Research output: Contribution to journalArticlepeer-review

Abstract

Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite-inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.

Original languageEnglish (US)
Article numberabb4133
JournalScience Advances
Volume6
Issue number44
DOIs
StatePublished - Oct 28 2020

ASJC Scopus subject areas

  • General

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