Gastrointestinal polyposis syndromes

Lodewijk A.A. Brosens; W. Arnout van Hattem; Marnix Jansen; Wendy W.J. de Leng; Francis M. Giardiello; G. Johan A. Offerhaus

doi:10.2174/156652407779940404

Gastrointestinal polyposis syndromes

Lodewijk A.A. Brosens, W. Arnout van Hattem, Marnix Jansen, Wendy W.J. de Leng, Francis M. Giardiello, G. Johan A. Offerhaus

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).

Original language	English (US)
Pages (from-to)	29-46
Number of pages	18
Journal	Current Molecular Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.2174/156652407779940404
State	Published - Feb 2007

Keywords

APC mutations
Chemoprevention
Colorectum
Desmoid tumors
Familial adenomatous polyposis (FAP)

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

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10.2174/156652407779940404

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title = "Gastrointestinal polyposis syndromes",

abstract = "Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).",

keywords = "APC mutations, Chemoprevention, Colorectum, Desmoid tumors, Familial adenomatous polyposis (FAP)",

author = "Brosens, {Lodewijk A.A.} and {van Hattem}, {W. Arnout} and Marnix Jansen and {de Leng}, {Wendy W.J.} and Giardiello, {Francis M.} and Offerhaus, {G. Johan A.}",

note = "Funding Information: This publication was supported in part by the Grace J. Fippinger Foundation, New York, New York.",

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doi = "10.2174/156652407779940404",

language = "English (US)",

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pages = "29--46",

journal = "Current Molecular Medicine",

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T1 - Gastrointestinal polyposis syndromes

AU - Brosens, Lodewijk A.A.

AU - van Hattem, W. Arnout

AU - Jansen, Marnix

AU - de Leng, Wendy W.J.

AU - Giardiello, Francis M.

AU - Offerhaus, G. Johan A.

N1 - Funding Information: This publication was supported in part by the Grace J. Fippinger Foundation, New York, New York.

PY - 2007/2

Y1 - 2007/2

N2 - Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).

AB - Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).

KW - APC mutations

KW - Chemoprevention

KW - Colorectum

KW - Desmoid tumors

KW - Familial adenomatous polyposis (FAP)

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Gastrointestinal polyposis syndromes

Abstract

Keywords

ASJC Scopus subject areas

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