Gastrointestinal polyposis syndromes

Lodewijk A.A. Brosens, W. Arnout van Hattem, Marnix Jansen, Wendy W.J. de Leng, Francis M. Giardiello, G. Johan A. Offerhaus

Research output: Contribution to journalReview articlepeer-review

Abstract

Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).

Original languageEnglish (US)
Pages (from-to)29-46
Number of pages18
JournalCurrent Molecular Medicine
Volume7
Issue number1
DOIs
StatePublished - Feb 2007

Keywords

  • APC mutations
  • Chemoprevention
  • Colorectum
  • Desmoid tumors
  • Familial adenomatous polyposis (FAP)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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