Gastric wall healing after NOTES procedures: Closure with endoscopic clips provides superior histological outcome compared with threaded tags closure

Xavier Dray, Devi M. Krishnamurty, Gianfranko Donatelli, Kathleen L Gabrielson, Ronald J. Wroblewski, Eun Shin, Samuel A. Giday, Jonathan M. Buscaglia, Laurie J. Pipitone, Michael Marohn, Anthony N Kalloo, Sergey V. Kantsevoy

Research output: Contribution to journalArticle

Abstract

Background: Closure of the transgastric access to the peritoneal cavity is a critical step in natural orifice transluminal endoscopic surgery (NOTES). Objective: To perform a direct comparison of the histological healing post clips and threaded tags (T-tags) closure after transgastric NOTES procedures. Setting: Design and Intervention: Twelve survival porcine experiments. After standardized endoscopic gastric wall puncture, balloon-dilation, and transgastric peritoneoscopy, closure of the gastric wall was performed with either clips or T-tags. Necropsy at 14 days was performed for histological evaluation of 2-mm interval transversal cross sections of the gastrotomy site. Main Outcome Measurements: Histological healing of the gastric wall opening. Results: Endoscopic closure of the gastrotomy was successfully achieved in all 12 animals, followed by an uneventful 2-week clinical follow-up. Transmural healing was seen in 3 (75%) animals after clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .06). Gastric wall muscular bridging was observed in 4 (100%) animals with clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .01). Limitations: Animal model with short-term follow-up. Conclusions: Endoscopic clip closure results in a layer-to-layer transmural healing of the gastric wall. In contrast, T-tag gastric wall plication impairs gastric layer bridging. These findings might guide the future design of new endoscopic devices and techniques for gastrotomy closure after NOTES procedures.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalGastrointestinal Endoscopy
Volume72
Issue number2
DOIs
StatePublished - Aug 2010

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Natural Orifice Endoscopic Surgery
Surgical Instruments
Stomach
Peritoneal Cavity
Punctures
Laparoscopy
Dilatation
Swine
Animal Models
Equipment and Supplies

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

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Gastric wall healing after NOTES procedures : Closure with endoscopic clips provides superior histological outcome compared with threaded tags closure. / Dray, Xavier; Krishnamurty, Devi M.; Donatelli, Gianfranko; Gabrielson, Kathleen L; Wroblewski, Ronald J.; Shin, Eun; Giday, Samuel A.; Buscaglia, Jonathan M.; Pipitone, Laurie J.; Marohn, Michael; Kalloo, Anthony N; Kantsevoy, Sergey V.

In: Gastrointestinal Endoscopy, Vol. 72, No. 2, 08.2010, p. 343-350.

Research output: Contribution to journalArticle

Dray, Xavier ; Krishnamurty, Devi M. ; Donatelli, Gianfranko ; Gabrielson, Kathleen L ; Wroblewski, Ronald J. ; Shin, Eun ; Giday, Samuel A. ; Buscaglia, Jonathan M. ; Pipitone, Laurie J. ; Marohn, Michael ; Kalloo, Anthony N ; Kantsevoy, Sergey V. / Gastric wall healing after NOTES procedures : Closure with endoscopic clips provides superior histological outcome compared with threaded tags closure. In: Gastrointestinal Endoscopy. 2010 ; Vol. 72, No. 2. pp. 343-350.
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abstract = "Background: Closure of the transgastric access to the peritoneal cavity is a critical step in natural orifice transluminal endoscopic surgery (NOTES). Objective: To perform a direct comparison of the histological healing post clips and threaded tags (T-tags) closure after transgastric NOTES procedures. Setting: Design and Intervention: Twelve survival porcine experiments. After standardized endoscopic gastric wall puncture, balloon-dilation, and transgastric peritoneoscopy, closure of the gastric wall was performed with either clips or T-tags. Necropsy at 14 days was performed for histological evaluation of 2-mm interval transversal cross sections of the gastrotomy site. Main Outcome Measurements: Histological healing of the gastric wall opening. Results: Endoscopic closure of the gastrotomy was successfully achieved in all 12 animals, followed by an uneventful 2-week clinical follow-up. Transmural healing was seen in 3 (75{\%}) animals after clip closure compared with only 1 (12.5{\%}) in the group with T-tag closure (P = .06). Gastric wall muscular bridging was observed in 4 (100{\%}) animals with clip closure compared with only 1 (12.5{\%}) in the group with T-tag closure (P = .01). Limitations: Animal model with short-term follow-up. Conclusions: Endoscopic clip closure results in a layer-to-layer transmural healing of the gastric wall. In contrast, T-tag gastric wall plication impairs gastric layer bridging. These findings might guide the future design of new endoscopic devices and techniques for gastrotomy closure after NOTES procedures.",
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AU - Krishnamurty, Devi M.

AU - Donatelli, Gianfranko

AU - Gabrielson, Kathleen L

AU - Wroblewski, Ronald J.

AU - Shin, Eun

AU - Giday, Samuel A.

AU - Buscaglia, Jonathan M.

AU - Pipitone, Laurie J.

AU - Marohn, Michael

AU - Kalloo, Anthony N

AU - Kantsevoy, Sergey V.

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N2 - Background: Closure of the transgastric access to the peritoneal cavity is a critical step in natural orifice transluminal endoscopic surgery (NOTES). Objective: To perform a direct comparison of the histological healing post clips and threaded tags (T-tags) closure after transgastric NOTES procedures. Setting: Design and Intervention: Twelve survival porcine experiments. After standardized endoscopic gastric wall puncture, balloon-dilation, and transgastric peritoneoscopy, closure of the gastric wall was performed with either clips or T-tags. Necropsy at 14 days was performed for histological evaluation of 2-mm interval transversal cross sections of the gastrotomy site. Main Outcome Measurements: Histological healing of the gastric wall opening. Results: Endoscopic closure of the gastrotomy was successfully achieved in all 12 animals, followed by an uneventful 2-week clinical follow-up. Transmural healing was seen in 3 (75%) animals after clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .06). Gastric wall muscular bridging was observed in 4 (100%) animals with clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .01). Limitations: Animal model with short-term follow-up. Conclusions: Endoscopic clip closure results in a layer-to-layer transmural healing of the gastric wall. In contrast, T-tag gastric wall plication impairs gastric layer bridging. These findings might guide the future design of new endoscopic devices and techniques for gastrotomy closure after NOTES procedures.

AB - Background: Closure of the transgastric access to the peritoneal cavity is a critical step in natural orifice transluminal endoscopic surgery (NOTES). Objective: To perform a direct comparison of the histological healing post clips and threaded tags (T-tags) closure after transgastric NOTES procedures. Setting: Design and Intervention: Twelve survival porcine experiments. After standardized endoscopic gastric wall puncture, balloon-dilation, and transgastric peritoneoscopy, closure of the gastric wall was performed with either clips or T-tags. Necropsy at 14 days was performed for histological evaluation of 2-mm interval transversal cross sections of the gastrotomy site. Main Outcome Measurements: Histological healing of the gastric wall opening. Results: Endoscopic closure of the gastrotomy was successfully achieved in all 12 animals, followed by an uneventful 2-week clinical follow-up. Transmural healing was seen in 3 (75%) animals after clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .06). Gastric wall muscular bridging was observed in 4 (100%) animals with clip closure compared with only 1 (12.5%) in the group with T-tag closure (P = .01). Limitations: Animal model with short-term follow-up. Conclusions: Endoscopic clip closure results in a layer-to-layer transmural healing of the gastric wall. In contrast, T-tag gastric wall plication impairs gastric layer bridging. These findings might guide the future design of new endoscopic devices and techniques for gastrotomy closure after NOTES procedures.

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