Gastric rupture and necrosis in Prader-Willi syndrome

David A. Stevenson, Janalee Heinemann, Moris Angulo, Merlin G. Butler, Jim Loker, Norma Rupe, Patrick Kendell, Suzanne B. Cassidy, Ann Scheimann

Research output: Contribution to journalArticle

Abstract

Hyperphagia and obesity are common features in individuals with Prader-Willi syndrome (PWS). Demographic and cause-of-death data from individuals with PWS were obtained through a national support organization. Four reports of unexpected mortality due to gastric rupture and necrosis were found in 152 reported deaths, accounting for 3% of the causes of mortality. Four additional individuals were suspected to have gastric rupture. Vomiting and abdominal pain, although rare in PWS, were frequent findings in this cohort. The physician should consider an emergent evaluation for gastric rupture and necrosis in individuals with PWS who present with vomiting and abdominal pain.

Original languageEnglish (US)
Pages (from-to)272-274
Number of pages3
JournalJournal of pediatric gastroenterology and nutrition
Volume45
Issue number2
DOIs
StatePublished - Aug 1 2007

Keywords

  • Gastric necrosis
  • Gastric perforation
  • Hyperphagia
  • Mortality
  • Prader-Willi syndrome
  • Vomiting

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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    Stevenson, D. A., Heinemann, J., Angulo, M., Butler, M. G., Loker, J., Rupe, N., Kendell, P., Cassidy, S. B., & Scheimann, A. (2007). Gastric rupture and necrosis in Prader-Willi syndrome. Journal of pediatric gastroenterology and nutrition, 45(2), 272-274. https://doi.org/10.1097/MPG.0b013e31805b82b5