Gastric rupture and necrosis in Prader-Willi syndrome

David A. Stevenson; Janalee Heinemann; Moris Angulo; Merlin G. Butler; Jim Loker; Norma Rupe; Patrick Kendell; Suzanne B. Cassidy; Ann Scheimann

doi:10.1097/MPG.0b013e31805b82b5

Gastric rupture and necrosis in Prader-Willi syndrome

David A. Stevenson, Janalee Heinemann, Moris Angulo, Merlin G. Butler, Jim Loker, Norma Rupe, Patrick Kendell, Suzanne B. Cassidy, Ann Scheimann

School of Medicine

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Hyperphagia and obesity are common features in individuals with Prader-Willi syndrome (PWS). Demographic and cause-of-death data from individuals with PWS were obtained through a national support organization. Four reports of unexpected mortality due to gastric rupture and necrosis were found in 152 reported deaths, accounting for 3% of the causes of mortality. Four additional individuals were suspected to have gastric rupture. Vomiting and abdominal pain, although rare in PWS, were frequent findings in this cohort. The physician should consider an emergent evaluation for gastric rupture and necrosis in individuals with PWS who present with vomiting and abdominal pain.

Original language	English (US)
Pages (from-to)	272-274
Number of pages	3
Journal	Journal of pediatric gastroenterology and nutrition
Volume	45
Issue number	2
DOIs	https://doi.org/10.1097/MPG.0b013e31805b82b5
State	Published - Aug 2007

Keywords

Gastric necrosis
Gastric perforation
Hyperphagia
Mortality
Prader-Willi syndrome
Vomiting

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Gastroenterology

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10.1097/MPG.0b013e31805b82b5

Cite this

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title = "Gastric rupture and necrosis in Prader-Willi syndrome",

abstract = "Hyperphagia and obesity are common features in individuals with Prader-Willi syndrome (PWS). Demographic and cause-of-death data from individuals with PWS were obtained through a national support organization. Four reports of unexpected mortality due to gastric rupture and necrosis were found in 152 reported deaths, accounting for 3% of the causes of mortality. Four additional individuals were suspected to have gastric rupture. Vomiting and abdominal pain, although rare in PWS, were frequent findings in this cohort. The physician should consider an emergent evaluation for gastric rupture and necrosis in individuals with PWS who present with vomiting and abdominal pain.",

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AU - Heinemann, Janalee

AU - Angulo, Moris

AU - Butler, Merlin G.

AU - Loker, Jim

AU - Rupe, Norma

AU - Kendell, Patrick

AU - Cassidy, Suzanne B.

AU - Scheimann, Ann

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AB - Hyperphagia and obesity are common features in individuals with Prader-Willi syndrome (PWS). Demographic and cause-of-death data from individuals with PWS were obtained through a national support organization. Four reports of unexpected mortality due to gastric rupture and necrosis were found in 152 reported deaths, accounting for 3% of the causes of mortality. Four additional individuals were suspected to have gastric rupture. Vomiting and abdominal pain, although rare in PWS, were frequent findings in this cohort. The physician should consider an emergent evaluation for gastric rupture and necrosis in individuals with PWS who present with vomiting and abdominal pain.

KW - Gastric necrosis

KW - Gastric perforation

KW - Hyperphagia

KW - Mortality

KW - Prader-Willi syndrome

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Gastric rupture and necrosis in Prader-Willi syndrome

Abstract

Keywords

ASJC Scopus subject areas

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