TY - JOUR
T1 - Gastric myoelectrical activity in healthy children and children with functional dyspepsia
AU - Chen, J. D.Z.
AU - Lin, Xuemei
AU - Zhang, Ming
AU - Torres-Pinedo, Ramon B.
AU - Orr, William C.
N1 - Funding Information:
These research results we re made possible by the OCAST award for project number H97-045 from the Oklahoma Center for the Advancement of Science and Tech-nolog. Tyhe authors would also like to thank Jie Pan, MS, for her technical assistance in this work.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - The aim of this study was to investigate abnormalities in pediatric patients with functional dyspepsia. Fifteen symptomatic pediatric patients diagnosed with functional dyspepsia and 17 aged-matched healthy controls were studied. Gastric myoelectrical activity was recorded using surface; electrogastrography for 1 hr in the fasting state and 1 hr after a test meal. It was found that, in comparison with the controls, the children with functional dyspepsia had a lower percentage of 2- to 4-cpm slow waves in both fasting state (66.0 ± 4.7% vs 79.7 ± 3.1%, P < 0.07) and fed state (72.4 ± 5.4% vs 85.0 ± 2.9%, P < 0.04), and a significantly higher instability of the dominant frequency in both fasting state (0.50 ± 0.05 vs 0.31 ± 0.04, P < 0.01) and fed state (0.39 ± 0.05 vs 0.25 ± 0.03, P < 0.05). It was also found the postprandial increase in EGG dominant power in the patients was inversely correlated with the total symptom score (r = 0.63, P = 0.03). It was concluded that abnormal gastric myoelectrical activity may play a role in the pathogenesis of pediatric functional dyspepsia.
AB - The aim of this study was to investigate abnormalities in pediatric patients with functional dyspepsia. Fifteen symptomatic pediatric patients diagnosed with functional dyspepsia and 17 aged-matched healthy controls were studied. Gastric myoelectrical activity was recorded using surface; electrogastrography for 1 hr in the fasting state and 1 hr after a test meal. It was found that, in comparison with the controls, the children with functional dyspepsia had a lower percentage of 2- to 4-cpm slow waves in both fasting state (66.0 ± 4.7% vs 79.7 ± 3.1%, P < 0.07) and fed state (72.4 ± 5.4% vs 85.0 ± 2.9%, P < 0.04), and a significantly higher instability of the dominant frequency in both fasting state (0.50 ± 0.05 vs 0.31 ± 0.04, P < 0.01) and fed state (0.39 ± 0.05 vs 0.25 ± 0.03, P < 0.05). It was also found the postprandial increase in EGG dominant power in the patients was inversely correlated with the total symptom score (r = 0.63, P = 0.03). It was concluded that abnormal gastric myoelectrical activity may play a role in the pathogenesis of pediatric functional dyspepsia.
KW - Electrogastrography
KW - Functional dyspepsia
KW - Gastric emptying
KW - Gastrointestinal motility
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U2 - 10.1023/A:1026661627304
DO - 10.1023/A:1026661627304
M3 - Article
C2 - 9824123
AN - SCOPUS:0031773494
SN - 0163-2116
VL - 43
SP - 2384
EP - 2391
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 11
ER -