Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans

Hassan Brim, Marwah Zahaf, Adeyinka O. Laiyemo, Mehdi Nouraie, Guillermo I. Pérez-Pérez, Duane T. Smoot, Edward Lee, Hadie Razjouyan, Hassan Ashktorab

Research output: Contribution to journalArticle

Abstract

Background: Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans.Methods: Medical records of African Americans, 40 years and older (n = 1256) who underwent bidirectional gastrointestinal endoscopy on the same day were reviewed. H. pylori status was assessed by immunohistochemistry on gastric specimens. Colorectal polyps were confirmed by histological examination of colorectal biopsies. A subset of serum samples from healthy and polyp-bearing patients (n = 163) were analyzed by ELISA for anti-H. pylori and anti-CagA antibodies. The crude and adjusted effect of H. pylori on the risk of colorectal adenoma and polyp were computed by logistic regression models.Results: The prevalence of colorectal polyps and adenomas were 456 (36%) and 300 (24%) respectively. Colorectal polyps were more prevalent in gastric H. pylori infected than non-infected subjects [43% vs. 34%; Odds Ratio (OR) (95% CI): 1.5 (1.2-1.9), P = 0.001]. Patients with H. pylori-associated chronic active gastritis were at high risk to have adenomas [Unadjusted OR (95% CI): 1.3 (1.0-1.8); P = 0.04]. There was no difference in histopathology, size, or location of polyps with respect to H. pylori status. Gastric H. pylori infection, age, male gender and high risk clinical presentations were independent risk factors for colorectal polyps. Serological testing also revealed a higher prevalence of H. pylori and its toxin Cag-A in polyp patients vs. non polyp patients' sera, although in a non-statistically significant manner.Conclusions: This study showed that current gastric H. pylori infection is associated with an increased risk of colorectal polyps in African Americans. Patients with H. pylori induced gastritis may benefit from early screening colonoscopy as a preventative measure for colorectal cancer.

Original languageEnglish (US)
Article number296
JournalBMC Cancer
Volume14
Issue number1
DOIs
StatePublished - Apr 28 2014
Externally publishedYes

Fingerprint

Helicobacter Infections
Polyps
Helicobacter pylori
African Americans
Stomach
Adenoma
Gastritis
Logistic Models
Odds Ratio
Gastrointestinal Endoscopy
Colonoscopy
Serum
Medical Records
Anti-Idiotypic Antibodies
Colorectal Neoplasms
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Biopsy

Keywords

  • African Americans
  • Colorectal neoplasm
  • Forty year and older
  • Gastric lesion
  • H. pylori infection
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Brim, H., Zahaf, M., Laiyemo, A. O., Nouraie, M., Pérez-Pérez, G. I., Smoot, D. T., ... Ashktorab, H. (2014). Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer, 14(1), [296]. https://doi.org/10.1186/1471-2407-14-296

Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. / Brim, Hassan; Zahaf, Marwah; Laiyemo, Adeyinka O.; Nouraie, Mehdi; Pérez-Pérez, Guillermo I.; Smoot, Duane T.; Lee, Edward; Razjouyan, Hadie; Ashktorab, Hassan.

In: BMC Cancer, Vol. 14, No. 1, 296, 28.04.2014.

Research output: Contribution to journalArticle

Brim, H, Zahaf, M, Laiyemo, AO, Nouraie, M, Pérez-Pérez, GI, Smoot, DT, Lee, E, Razjouyan, H & Ashktorab, H 2014, 'Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans', BMC Cancer, vol. 14, no. 1, 296. https://doi.org/10.1186/1471-2407-14-296
Brim, Hassan ; Zahaf, Marwah ; Laiyemo, Adeyinka O. ; Nouraie, Mehdi ; Pérez-Pérez, Guillermo I. ; Smoot, Duane T. ; Lee, Edward ; Razjouyan, Hadie ; Ashktorab, Hassan. / Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. In: BMC Cancer. 2014 ; Vol. 14, No. 1.
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abstract = "Background: Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans.Methods: Medical records of African Americans, 40 years and older (n = 1256) who underwent bidirectional gastrointestinal endoscopy on the same day were reviewed. H. pylori status was assessed by immunohistochemistry on gastric specimens. Colorectal polyps were confirmed by histological examination of colorectal biopsies. A subset of serum samples from healthy and polyp-bearing patients (n = 163) were analyzed by ELISA for anti-H. pylori and anti-CagA antibodies. The crude and adjusted effect of H. pylori on the risk of colorectal adenoma and polyp were computed by logistic regression models.Results: The prevalence of colorectal polyps and adenomas were 456 (36{\%}) and 300 (24{\%}) respectively. Colorectal polyps were more prevalent in gastric H. pylori infected than non-infected subjects [43{\%} vs. 34{\%}; Odds Ratio (OR) (95{\%} CI): 1.5 (1.2-1.9), P = 0.001]. Patients with H. pylori-associated chronic active gastritis were at high risk to have adenomas [Unadjusted OR (95{\%} CI): 1.3 (1.0-1.8); P = 0.04]. There was no difference in histopathology, size, or location of polyps with respect to H. pylori status. Gastric H. pylori infection, age, male gender and high risk clinical presentations were independent risk factors for colorectal polyps. Serological testing also revealed a higher prevalence of H. pylori and its toxin Cag-A in polyp patients vs. non polyp patients' sera, although in a non-statistically significant manner.Conclusions: This study showed that current gastric H. pylori infection is associated with an increased risk of colorectal polyps in African Americans. Patients with H. pylori induced gastritis may benefit from early screening colonoscopy as a preventative measure for colorectal cancer.",
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AU - Pérez-Pérez, Guillermo I.

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