Gastric Function in Children with Cystic Fibrosis: Effect of Diet on Gastric Lipase Levels and Fat Digestion

Martine Armand, Margit Hamosh, Jessica R. Philpott, Amy Kovar Resnik, Beryl J Rosenstein, Ada Hamosh, Jay A. Perman, Paul Hamosh

Research output: Contribution to journalArticle

Abstract

The effect of diet, usual (44 ± 4% energy as fat), high-fat (49 ± 4% energy as fat), and moderate-fat (33 ± 2% energy as fat), on gastric function (lipase and pepsin activities, pH, emptying rate) and intragastric digestion of fat were assessed in six children with cystic fibrosis. Fasting and postprandial activity of digestive enzymes, gastric pH, and gastric volume measured before, during, and after 120 min of feeding did not differ significantly as a function of fat intake. Postprandial gastric lipase output (units per kilogram of body weight) during usual, moderate-fat, and high-fat diets was close to or higher than (38.8 ± 7.2, 44.9 ± 8.6, and 54.8 ± 5.5 U/kg per 20 min) gastric lipase output of premature infants (22.5 ± 6.4 to 28.3 ± 6.6 U/kg per 20 min) or of healthy adults (5.4 ± 0.4 U/kg per 15 min) fed a high-fat diet. Postprandial pepsin output was higher (4749 ± 797, 6117 ± 925, and 5444 ± 819 U/kg per 20 min) than in premature infants (597 ± 77 to 743 ± 97 U/kg per 20 min) or healthy adults (781 ± 56 U/kg per 15 min). Eighty minutes after feeding gastric lipolysis reached 20 to 36%. This study shows that gastric lipase activity is high in cystic fibrosis patients maintained on diets providing 32% to 49% energy as fat, and that gastric lipase level did not increase over the ranges of dietary fat intake tested.

Original languageEnglish (US)
Pages (from-to)457-465
Number of pages9
JournalPediatric Research
Volume55
Issue number3
DOIs
StatePublished - Mar 2004

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Lipase
Cystic Fibrosis
Digestion
Stomach
Fats
Diet
Pepsin A
High Fat Diet
Premature Infants
Lipolysis
Dietary Fats
Fasting
Body Weight
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gastric Function in Children with Cystic Fibrosis : Effect of Diet on Gastric Lipase Levels and Fat Digestion. / Armand, Martine; Hamosh, Margit; Philpott, Jessica R.; Resnik, Amy Kovar; Rosenstein, Beryl J; Hamosh, Ada; Perman, Jay A.; Hamosh, Paul.

In: Pediatric Research, Vol. 55, No. 3, 03.2004, p. 457-465.

Research output: Contribution to journalArticle

Armand, Martine ; Hamosh, Margit ; Philpott, Jessica R. ; Resnik, Amy Kovar ; Rosenstein, Beryl J ; Hamosh, Ada ; Perman, Jay A. ; Hamosh, Paul. / Gastric Function in Children with Cystic Fibrosis : Effect of Diet on Gastric Lipase Levels and Fat Digestion. In: Pediatric Research. 2004 ; Vol. 55, No. 3. pp. 457-465.
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