Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis

A. Kedar, Y. Nikitina, K. B. Abell, V. Vedanarayanan, M. E. Griswold, C. Subramony, T. L. Abell

Research output: Contribution to journalArticle

Abstract

Nutritional abnormalities are common in patients with gastroparesis (Gp), a disorder that may affect gastric motility and may delay emptying. The aim of this work was to identify relationships between serum nutrition markers including 25-OH vitamin D and gastric motility measures in Gp patients. We enrolled 59 consecutive gastric motility clinic patients (48 females, 11 males; mean age 44 years; 42 idiopathic; 17 diabetes mellitus) with Gp symptoms. The 25-OH vitamin D levels, for most patients slightly above the lower limit of normal (96.98 nmol/l±60.99), were lowest in diabetic range (DM) (75.68 nmol/l±34.22) vs. idiopathic (ID) (105.03 nmol/l±67.08) gastroparesis patients. First hour GET: one unit increase in 25-OH vitamin D level was associated 0.11% improvement (95% CI - 0.22, 0.01 p=0.056) in gastric motility in all patients; this association, although marked in ID Gp patients, (- 0.13, CI - 0.25, - 0.01 p=0.034), was not seen in DM Gp, (0.2, CI - 0.45, 0.87, p=0.525). Fourth hour GET: Every unit increase of 25-OH vitamin D was associated with significant improvement in all patients, (0.11% CI - 0.23, 0.01, p=0.053), and some weak improvement in ID group, (0.11% - 0.24, 0.01, p=0.076) and absent in patients with DM (0.03, CI - 0.66, 0.72, p=0.932). It is concluded that 25-OH vitamin D levels may influence gastric emptying. Underlying mechanisms for this observation might include the impact of 25-OH vitamin D on the health of the enteric nervous system. 25-OH vitamin D contributions to enteric nerve functions should be explored, particularly where autonomic nervous system comorbidities exist.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalHormone and Metabolic Research
Volume45
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Gastroparesis
Vitamin D
Stomach
Serum
Neurology
Nutrition
Enteric Nervous System
Medical problems
Gastric Emptying
Autonomic Nervous System
Health
Comorbidity
Diabetes Mellitus
Biomarkers

Keywords

  • autonomic nervous system (ANS)
  • diabetes
  • gastric emptying test (GET)
  • gastroparesis
  • low vitamins D

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Kedar, A., Nikitina, Y., Abell, K. B., Vedanarayanan, V., Griswold, M. E., Subramony, C., & Abell, T. L. (2013). Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis. Hormone and Metabolic Research, 45(1), 47-53. https://doi.org/10.1055/s-0032-1323689

Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis. / Kedar, A.; Nikitina, Y.; Abell, K. B.; Vedanarayanan, V.; Griswold, M. E.; Subramony, C.; Abell, T. L.

In: Hormone and Metabolic Research, Vol. 45, No. 1, 2013, p. 47-53.

Research output: Contribution to journalArticle

Kedar, A, Nikitina, Y, Abell, KB, Vedanarayanan, V, Griswold, ME, Subramony, C & Abell, TL 2013, 'Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis', Hormone and Metabolic Research, vol. 45, no. 1, pp. 47-53. https://doi.org/10.1055/s-0032-1323689
Kedar A, Nikitina Y, Abell KB, Vedanarayanan V, Griswold ME, Subramony C et al. Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis. Hormone and Metabolic Research. 2013;45(1):47-53. https://doi.org/10.1055/s-0032-1323689
Kedar, A. ; Nikitina, Y. ; Abell, K. B. ; Vedanarayanan, V. ; Griswold, M. E. ; Subramony, C. ; Abell, T. L. / Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis. In: Hormone and Metabolic Research. 2013 ; Vol. 45, No. 1. pp. 47-53.
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