Acid secretion in Pavlov pouches in dogs is known to increase after antrectomy in response to histamine and gastrin. Dogs with gastric fistulae were tested with histamine and tetragastrin as a control study. The vagal nerve fibers to the antrum were divided and the dogs underwent repeat testing. Finally an antrectomy was performed and final dose response data were collected. After antrectomy there was an increased acid response to histamine and tetragastrin. It is postulated that the vagal fibers innervating the antrum are probably not a factor in this increase. The increased acid secretion after antrectomy observed in the dog and the decrease known to occur in the human being is considered to be a species difference and is not related to the pouch method of study used in earlier studies of the antrectomized dog.
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