Ganzfeld electroretinographic findings in Parkinsonism: Untreated patients and the effect of levodopa intravenous infusion

M. J. Jaffe, G. Bruno, G. Campbell, R. A. Lavine, C. N. Karson, D. R. Weinberger

Research output: Contribution to journalArticle

Abstract

Two groups of patients with primary Parkinsonism were studied with the ganzfeld electroretinogram (ERG): (1) seven patients who had never received dopamimetic agents, and (2) six patients given an infusion of levodopa following a period of medication withdrawal. Patients in the first category had a subtle increase in the latency of their short-wavelength sensitive cone response recorded from the retina ipsilateral to their more symptomatic side. Most patients in the second category demonstrate an improvement in their ERG when the responses recorded following levodopa infusion were compared with baseline responses obtained during the period of medication withdrawal. These results suggest that one role of retinal dopamine may be maintenance of normal retinal responsiveness to flash stimuli.

Original languageEnglish (US)
Pages (from-to)847-852
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume50
Issue number7
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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