TY - JOUR
T1 - Ganirelix acetate causes a rapid reduction in estradiol levels without adversely affecting oocyte maturation in women pretreated with leuprolide acetate who are at risk of ovarian hyperstimulation syndrome
AU - Gustofson, Robert L.
AU - Segars, James H.
AU - Larsen, Frederick W.
N1 - Funding Information:
This research was supported, in part, by the Intramural Research Program of the Reproductive Biology and Medicine Branch, NICHD, NIH.
PY - 2006/11
Y1 - 2006/11
N2 - Background: Elevated estradiol (E 2) levels predispose to development of ovarian hyperstimulation syndrome (OHSS). Since GnRH antagonist is associated with a reduction in E 2 levels, we hypothesized that GnRH-antagonist treatment of women down-regulated with GnRH agonist who are at risk of OHSS might reduce E 2 levels and avoid cycle cancellation. Methods: Retrospective study in a university-based assist ed reproduction technology (ART) programme in 87 patients treated with long luteal (LL) or microdose flare (MDF) with ovarian hyperresponse and 87 control patients without ovarian hyperresponse. GnRH-antagonist (ganirelix acetate) treatment was started and leuprolide acetate discontinued in women who failed to respond to a reduction in gonadotrophin dosage. Results: In the treatment group, there was a sign ificant, reproducible reduction in serum E 2 levels. Mean E 2 at the start of ganirelix treatment was 4219.8 pg/ml and decreased in 24 h to 2613.7 pg/ml (36.7%; P < 0.001). An average of 24.9 ± 8.8 oocytes were obtained at retrieval and an average of 19.1 ± 8.0 were metaphase II (79.2%). Fertilization occurred in 13.9 ± 8.1 embryos (72.8%). In this high risk group, two cases of severe OHSS (2.3%) occurred. The ongoing pregnancy rate was 51.8%. Compared with the control group, there were no statistically significant differences in the rate of oocyte recovery, oocyte maturity, 2PN rate, fertilization, cancellation, OHSS or pregnancy. Conclusions: GnRH-antagonist treatment of women pretreated w ith GnRH agonist rapidly reduced circulating serum E 2 without adversely affecting oocyte maturation, fertilization rates or embryo quality and resulted in a high pregnancy rate in this subgroup of patients at risk of OHSS.
AB - Background: Elevated estradiol (E 2) levels predispose to development of ovarian hyperstimulation syndrome (OHSS). Since GnRH antagonist is associated with a reduction in E 2 levels, we hypothesized that GnRH-antagonist treatment of women down-regulated with GnRH agonist who are at risk of OHSS might reduce E 2 levels and avoid cycle cancellation. Methods: Retrospective study in a university-based assist ed reproduction technology (ART) programme in 87 patients treated with long luteal (LL) or microdose flare (MDF) with ovarian hyperresponse and 87 control patients without ovarian hyperresponse. GnRH-antagonist (ganirelix acetate) treatment was started and leuprolide acetate discontinued in women who failed to respond to a reduction in gonadotrophin dosage. Results: In the treatment group, there was a sign ificant, reproducible reduction in serum E 2 levels. Mean E 2 at the start of ganirelix treatment was 4219.8 pg/ml and decreased in 24 h to 2613.7 pg/ml (36.7%; P < 0.001). An average of 24.9 ± 8.8 oocytes were obtained at retrieval and an average of 19.1 ± 8.0 were metaphase II (79.2%). Fertilization occurred in 13.9 ± 8.1 embryos (72.8%). In this high risk group, two cases of severe OHSS (2.3%) occurred. The ongoing pregnancy rate was 51.8%. Compared with the control group, there were no statistically significant differences in the rate of oocyte recovery, oocyte maturity, 2PN rate, fertilization, cancellation, OHSS or pregnancy. Conclusions: GnRH-antagonist treatment of women pretreated w ith GnRH agonist rapidly reduced circulating serum E 2 without adversely affecting oocyte maturation, fertilization rates or embryo quality and resulted in a high pregnancy rate in this subgroup of patients at risk of OHSS.
KW - Cycle cancellation
KW - Estradiol
KW - Ganirelix acetate
KW - GnRH agonist and antagonist
KW - OHSS
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U2 - 10.1093/humrep/del059
DO - 10.1093/humrep/del059
M3 - Article
C2 - 16966348
AN - SCOPUS:33750023496
SN - 0268-1161
VL - 21
SP - 2830
EP - 2837
JO - Human Reproduction
JF - Human Reproduction
IS - 11
ER -