Galectin-3: A potential target for cancer prevention

Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyaya

Research output: Contribution to journalReview article

Abstract

Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalTrends in Carbohydrate Research
Volume3
Issue number2
StatePublished - Dec 1 2011

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Keywords

  • Angiogenesis
  • Apoptosis
  • Galectin-3
  • TF-disaccharide
  • Tumorigenesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Ahmed, H., Guha, P., Kaptan, E., & Bandyopadhyaya, G. (2011). Galectin-3: A potential target for cancer prevention. Trends in Carbohydrate Research, 3(2), 12-21.