Gadolinium-enhanced, vessel-tracking, two-dimensional coronary MR angiography: Single-dose arterial-phase vs. Delayed-phase imaging

Vincent B. Ho, Thomas K F Foo, Andrew E. Arai, Steven D. Wolff

Research output: Contribution to journalArticle

Abstract

The purposes of our study were to investigate the benefits of using a single dose of an extracellular contrast agent for coronary magnetic resonance angiography (CMRA) and to determine the relative benefits of arterial-phase vs. delayed-phase image acquisition. The right coronary artery was imaged in 10 healthy adults using a breath-hold, two-dimensional fast gradient echo pulse sequence designed for vessel tracking (multiphase, multislice image acquisition). Pre- and postcontrast CMRA was performed. Postcontrast imaging consisted of arterial- and delayed-phase CMRA following a 15 mL bolus (single dose) of contrast media and of delayed-phase imaging following a cumulative 45 mL contrast dose (triple dose). Contrast-enhanced CMRA provided a significantly higher (P <0.001) signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) than noncontrast CMRA. CNR was highest for single-dose arterial-phase CMRA (13.1 ± 4.5) and triple-dose delayed-phase CMRA (13.0 ± 4.8), followed by single-dose delayed-phase CMRA (8.4 ± 3.5) and noncontrast CMRA (4.2 ± 1.8). Single-dose arterial-phase CMRA provided the best visualization of the distal right coronary artery and was preferred for blinded physician assessments. We concluded that utilization of a single dose of extracellular contrast media improves CMRA, especially if timed for arterial-phase imaging.

Original languageEnglish (US)
Pages (from-to)682-689
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume13
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Arteries, coronary
  • Arteries, MR
  • Coronary vessels, MR
  • Gadolinium
  • Magnetic resonance, contrast enhancement
  • Magnetic resonance, vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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