Gadolinium-doped carbon quantum dots loaded magnetite nanoparticles as a bimodal nanoprobe for both fluorescence and magnetic resonance imaging

Yan Huang, Long Li, Donghui Zhang, Liping Gan, Pei Zhao, Yinfeng Zhang, Qi Zhang, Mingqing Hua, Chunman Jia

Research output: Contribution to journalArticlepeer-review

Abstract

Nowadays, it is highly desired to develop dual-modal fluorescence and magnetic resonance imaging (FI/MRI) probes in medical imaging because it unites the respective advantages of each imaging modality: high sensitivity of FI and superior spatial resolution of MRI. In this study, a facile strategy to fabricate a new bimodal imaging nanoprobe (Gd-CQDs@N-Fe3O4) was reported by integrating the fluorescence ability of carbon quantum dots (CQDs) and T1 and T2 contrast-enhancing functionality of Gd(III) ions and Fe3O4 nanoparticles into a single hybrid nanostructure. The hybrid composites were investigated by FT-IR, XRD, TEM, XPS, VSM, and so on, which confirmed that Gd-CQDs@N-Fe3O4 nanoparticles were successfully obtained and exhibited superparamagnetic property at room temperature. The derived nanoprobes presented an excitation wavelength-independent emission behavior. In addition, r1 and r2 relaxivities of the synthesized imaging nanoprobes were measured to be 5.16 and 115.6 mM 1 s 1, which nominated Gd-CQDs@N-Fe3O4 nanocomposites as a suitable T1-T2 contrast agent. The Gd-CQDs@N-Fe3O4 nanoparticles combining two synergetic imaging modalities showed great potential in FI/MRI dual-modal imaging for a more complementary and accurate detection.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalMagnetic Resonance Imaging
Volume68
DOIs
StatePublished - May 2020

Keywords

  • Dual-modal imaging
  • FeO
  • Fluorescence
  • Gd-doped carbon quantum dots
  • Relaxivity

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Gadolinium-doped carbon quantum dots loaded magnetite nanoparticles as a bimodal nanoprobe for both fluorescence and magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this