Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent

Zhiliang Cheng, Daniel L.J. Thorek, Andrew Tsourkas

Research output: Contribution to journalArticlepeer-review

Abstract

"Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number2
DOIs
StatePublished - Jan 8 2010

Keywords

  • Dendrimers
  • Gadolinium
  • Imaging agents
  • Magnetic resonance imaging
  • Tumors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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